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ONTOLOGY REPORT - ANNOTATIONS


Term:maslinic acid
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Accession:CHEBI:66682 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 2 and 3 and a carboxy group at position 28 (the 2alpha,3beta stereoisomer). It is isolated from Olea europaea and Salvia canariensis and exhibits anti-inflammatory, antioxidant and antineoplastic activity.
Synonyms:exact_synonym: (2alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid
 related_synonym: Crategolic acid;   Formula=C30H48O4;   InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1;   InChIKey=MDZKJHQSJHYOHJ-LLICELPBSA-N;   Masilinic acid;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@@H](O)[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
 xref: CAS:4373-41-5 "ChemIDplus";   CAS:4373-41-5 "KEGG COMPOUND";   HMDB:HMDB0002392;   KEGG:C16939
 xref_mesh: MESH:C412811
 xref: PMID:12802735 "Europe PMC";   PMID:21288041 "Europe PMC";   PMID:21309591 "Europe PMC";   PMID:21384845 "Europe PMC";   PMID:21973054 "Europe PMC";   PMID:23003682 "Europe PMC";   PMID:23175023 "Europe PMC";   Patent:CN102106861;   Patent:CN102579456;   Patent:US2011105611;   Patent:WO2011015692;   Reaxys:2711878 "Reaxys";   Wikipedia:Maslinic_acid


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maslinic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:6480464
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      chemical role 19189
        antioxidant 14093
          maslinic acid 13
            2-O-caffeoyl maslinic acid 0
            3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]maslinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        hydroxy carboxylic acid 3594
                                          hydroxy monocarboxylic acid 3594
                                            dihydroxy monocarboxylic acid 256
                                              maslinic acid 13
                                                2-O-caffeoyl maslinic acid 0
                                                3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]maslinic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.