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Term:phosphatoquinone A
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Accession:CHEBI:66751 term browser browse the term
Definition:An organic heterotricyclic compound resulting from the formal epoxidation of the 2-3 double bond of the 1,4-naphthoquinone moiety of phosphatoquinone B. It is isolated from the culture broth of Streptomyces sp.TC-0363 and exhibits inhibitory activity against the enzyme protein tyrosine phosphatase.
Synonyms:exact_synonym: (1aR,7aS)-7a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3,5-dihydroxy-1a-methyl-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione
 related_synonym: Formula=C21H24O5;   InChI=1S/C21H24O5/c1-12(2)6-5-7-13(3)8-9-21-18(24)15-10-14(22)11-16(23)17(15)19(25)20(21,4)26-21/h6,8,10-11,22-23H,5,7,9H2,1-4H3/b13-8+/t20-,21+/m0/s1;   InChIKey=QTORDDSSLVGNHO-BGTMZHHNSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\C[C@]12O[C@@]1(C)C(=O)c1c(O)cc(O)cc1C2=O
 xref: PMID:10344559 "Europe PMC";   Reaxys:8168625 "Reaxys"

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  CHEBI ontology 19716
    role 19663
      biological role 19661
        antimicrobial agent 17199
          phosphatoquinone A 0
Path 2
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  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteromonocyclic compound 16350
                                    saturated organic heteromonocyclic parent 5354
                                      oxirane 5314
                                        epoxide 5312
                                          phosphatoquinone A 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.