Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:vismodegib
go back to main search page
Accession:CHEBI:66903 term browser browse the term
Definition:A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Synonyms:exact_synonym: 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
 related_synonym: Erivedge;   Formula=C19H14Cl2N2O3S;   InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24);   InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1;   vismodegibum
 alt_id: MESH:C538724
 xref: CAS:879085-55-9;   Drug_Central:4227
 xref_mesh: MESH:C538724
 xref: PMID:21602311;   PMID:21610148;   PMID:21753154;   PMID:22458643;   PMID:22489352;   PMID:22618984;   PMID:22653209;   PMID:22670903;   PMID:22670904;   PMID:22679179;   PMID:22718857;   PMID:22777303;   PMID:22788238;   PMID:22805146;   PMID:22844657;   Reaxys:12532124;   Wikipedia:Vismodegib


show annotations for term's descendants       view all columns           Sort by:
 
vismodegib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:6480464
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:6480464
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:6480464
G Mycn MYCN proto-oncogene, bHLH transcription factor JBrowse link 6 38,222,554 38,228,419 RGD:6480464
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:6480464
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6480464
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:6480464
G Ptch2 patched 2 JBrowse link 5 135,962,252 135,983,816 RGD:6480464
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:6480464
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:6480464
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      biological role 19704
        aetiopathogenetic role 18816
          teratogenic agent 15875
            vismodegib 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      carboxylic acid 17978
                                        carboacyl group 17095
                                          univalent carboacyl group 17095
                                            carbamoyl group 16818
                                              carboxamide 16818
                                                monocarboxylic acid amide 14185
                                                  arenecarboxamide 6497
                                                    benzamides 6497
                                                      vismodegib 20
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.