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ONTOLOGY REPORT - ANNOTATIONS


Term:axitinib
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Accession:CHEBI:66910 term browser browse the term
Definition:An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms:exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
 related_synonym: AG-013736;   Formula=C22H18N4OS;   InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+;   InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N;   Inlyta;   N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide;   SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1;   axitinibum
 xref: CAS:319460-85-0 "ChemIDplus";   CAS:319460-85-0 "KEGG DRUG";   Drug_Central:4225 "DrugCentral";   KEGG:D03218
 xref_mesh: MESH:C503983
 xref: PMID:20740300 "Europe PMC";   PMID:21301929 "Europe PMC";   PMID:21670972 "Europe PMC";   PMID:22168366 "Europe PMC";   PMID:22170007 "Europe PMC";   PMID:22248343 "Europe PMC";   PMID:22504156 "Europe PMC";   PMID:22545314 "Europe PMC";   PMID:22549112 "Europe PMC";   PMID:22644797 "Europe PMC";   PMID:22683928 "Europe PMC";   PMID:22699078 "Europe PMC";   PMID:22706540 "Europe PMC";   PMID:22733795 "Europe PMC";   PMID:22787405 "Europe PMC";   Reaxys:11333336 "Reaxys";   Wikipedia:Axitinib


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axitinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              axitinib 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  arenecarboxamide 6485
                                                    benzamides 6485
                                                      axitinib 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.