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ONTOLOGY REPORT - ANNOTATIONS


Term:cortistatins
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Accession:CHEBI:67169 term browser browse the term
Definition:Any member of a class of steroidal alkaloids obtained from the marine sponge Corticium simplex, with a basic skeleton that is (5R,8beta)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs).
Synonyms:xref: PMID:16522087;   PMID:17765550;   PMID:19469509;   PMID:19722632;   PMID:19812680;   PMID:20463995;   PMID:20672014;   PMID:20861890;   PMID:20861906;   PMID:21311803;   PMID:21391624;   PMID:21405132;   PMID:22342595;   Wikipedia:Cortistatins


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      application 19363
        pharmaceutical 19233
          drug 19233
            angiogenesis modulating agent 1487
              cortistatins 0
                cortistatin A + 0
                cortistatin B + 0
                cortistatin C + 0
                cortistatin D 0
                cortistatin E 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    main group molecular entity 19655
                      s-block molecular entity 19398
                        hydrogen molecular entity 19388
                          hydrides 18363
                            inorganic hydride 17213
                              pnictogen hydride 17176
                                nitrogen hydride 17011
                                  azane 16704
                                    ammonia 16703
                                      organic amino compound 16702
                                        tertiary amino compound 8625
                                          cortistatins 0
                                            cortistatin A + 0
                                            cortistatin B + 0
                                            cortistatin C + 0
                                            cortistatin D 0
                                            cortistatin E 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.