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ONTOLOGY REPORT - ANNOTATIONS


Term:azadiradione
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Accession:CHEBI:67280 term browser browse the term
Definition:A tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities.
Synonyms:exact_synonym: (5alpha,7alpha,13alpha,17alpha)-17-(furan-3-yl)-4,4,8-trimethyl-3,16-dioxoandrosta-1,14-dien-7-yl acetate
 related_synonym: 24-Nor-5alpha,13alpha,17alpha-chola-1,14,20,22-tetraene-3,16-dione, 21,23-epoxy-7alpha-hydroxy-4,4,8-trimethyl-,acetate;   Formula=C28H34O5;   InChI=1S/C28H34O5/c1-16(29)33-23-14-20-25(2,3)22(31)8-11-26(20,4)19-7-10-27(5)21(28(19,23)6)13-18(30)24(27)17-9-12-32-15-17/h8-9,11-13,15,19-20,23-24H,7,10,14H2,1-6H3/t19-,20+,23-,24-,26-,27-,28-/m1/s1;   InChIKey=KWAMDQVQFVBEAU-HMWIRDDCSA-N;   SMILES=CC(=O)O[C@@H]1C[C@H]2C(C)(C)C(=O)C=C[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C(=O)C=C3[C@]12C)c1ccoc1
 xref: CAS:26241-51-0 "ChemIDplus"
 xref_mesh: MESH:C479321
 xref: PMID:12713364 "Europe PMC";   PMID:1593280 "Europe PMC";   PMID:18617378 "Europe PMC";   PMID:19475987 "Europe PMC";   PMID:22928548 "Europe PMC";   Reaxys:5858436 "Reaxys"


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azadiradione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        anti-inflammatory agent 14905
          azadiradione 4
            15-hydroxyazadiradione 0
            17-hydroxyazadiradione 0
            desfuranoazadiradione 0
            epoxyazadiradione + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      ketone 15780
                                        cyclic ketone 13089
                                          alicyclic ketone 1042
                                            cyclic terpene ketone 126
                                              azadiradione 4
                                                15-hydroxyazadiradione 0
                                                17-hydroxyazadiradione 0
                                                desfuranoazadiradione 0
                                                epoxyazadiradione + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.