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ONTOLOGY REPORT - ANNOTATIONS


Term:mephenytoin
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Accession:CHEBI:6757 term browser browse the term
Definition:An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Synonyms:exact_synonym: 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
 related_synonym: DL-Mephenytoin;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16);   InChIKey=GMHKMTDVRCWUDX-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2;   mefenitoina;   mephenytoine;   mephenytoinum;   methylphenetoin;   phenylethylmethylhydantoin
 alt_id: CHEBI:91914
 xref: CAS:50-12-4;   Drug_Central:1695;   KEGG:D00375;   LINCS:LSM-1852
 xref_mesh: MESH:D008617
 xref: PMID:11422005;   PMID:15282764;   PMID:25797720;   PMID:29438107;   Reaxys:17282;   Wikipedia:Mephenytoin


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mephenytoin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19789
    role 19735
      application 19381
        pharmaceutical 19251
          drug 19251
            central nervous system drug 16433
              central nervous system depressant 16006
                anticonvulsant 15152
                  mephenytoin 8
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Term Annotations click to browse term
  CHEBI ontology 19789
    subatomic particle 19787
      composite particle 19787
        hadron 19787
          baryon 19787
            nucleon 19787
              atomic nucleus 19787
                atom 19787
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19569
                        carbon atom 19558
                          organic molecular entity 19558
                            organic molecule 19480
                              organic cyclic compound 19239
                                organic heterocyclic compound 18352
                                  organic heteromonocyclic compound 16413
                                    diazolidine 582
                                      imidazolidines 572
                                        imidazolidinone 476
                                          imidazolidine-2,4-dione 455
                                            mephenytoin 8
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