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ONTOLOGY REPORT - ANNOTATIONS


Term:conivaptan
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Accession:CHEBI:681850 term browser browse the term
Definition:The amide resulting from the formal condensation of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid with the benzazepine nitrogen of 2-methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2. It is used as its hydrochloride salt for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH).
Synonyms:exact_synonym: N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
 related_synonym: 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide;   Formula=C32H26N4O2;   InChI=1S/C32H26N4O2/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);   InChIKey=IKENVDNFQMCRTR-UHFFFAOYSA-N;   SMILES=Cc1nc2CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc3-c2[nH]1
 xref: Beilstein:8658375 "Beilstein";   CAS:210101-16-9 "ChemIDplus";   CAS:210101-16-9 "KEGG DRUG";   DrugBank:DB00872;   Drug_Central:732 "DrugCentral";   KEGG:D07748;   PMID:20070106 "ChEMBL";   Wikipedia:Conivaptan


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Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        pharmacological role 18794
          antagonist 16201
            hormone antagonist 11319
              vasopressin receptor antagonist 0
                conivaptan 0
                  conivaptan hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      p-block molecular entity 19614
                        carbon group molecular entity 19506
                          organic molecular entity 19500
                            organic molecule 19418
                              organic cyclic compound 19189
                                organic heterocyclic compound 18267
                                  organic heteropolycyclic compound 17572
                                    organic heterobicyclic compound 16245
                                      benzazepine 488
                                        conivaptan 0
                                          conivaptan hydrochloride 0
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