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ONTOLOGY REPORT - ANNOTATIONS


Term:rivaroxaban
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Accession:CHEBI:68579 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery.
Synonyms:exact_synonym: 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
 related_synonym: BAY 59-7939;   BAY59-7939;   Formula=C19H18ClN3O5S;   InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1;   InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N;   SMILES=[H][C@]1(CNC(=O)c2ccc(Cl)s2)CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O;   Xarelto
 xref: CAS:366789-02-8 "ChemIDplus";   DrugBank:DB06228;   Drug_Central:4182 "DrugCentral";   KEGG:D07086;   LINCS:LSM-5499
 xref_mesh: MESH:D000069552
 xref: PDBeChem:RIV;   PMID:22042412 "Europe PMC";   PMID:22173426 "Europe PMC";   PMID:22187012 "Europe PMC";   PMID:22242932 "Europe PMC";   PMID:22272729 "Europe PMC";   PMID:22372178 "Europe PMC";   PMID:22387577 "Europe PMC";   PMID:22422332 "Europe PMC";   PMID:22533680 "Europe PMC";   PMID:22534269 "Europe PMC";   PMID:22534775 "Europe PMC";   PMID:22542983 "Europe PMC";   PMID:22651881 "Europe PMC";   PMID:22664783 "Europe PMC";   PMID:22701330 "Europe PMC";   PMID:22740145 "Europe PMC";   PMID:22777255 "Europe PMC";   PMID:22800431 "Europe PMC";   PMID:22811404 "Europe PMC";   PMID:22871192 "Europe PMC";   PMID:22884545 "Europe PMC";   PMID:22932305 "Europe PMC";   PMID:22958812 "Europe PMC";   PMID:23006523 "Europe PMC";   PMID:23014816 "Europe PMC";   Patent:EP1685841;   Patent:US2005182055;   Patent:US2007026065;   Patent:US2009036504;   Patent:US2010151011;   Patent:US2011034453;   Patent:US2011112083;   Patent:US2011152266;   Patent:US2011288294;   Patent:US7816355;   Patent:WO2004060887;   Patent:WO2005068456;   Patent:WO2008140220;   Patent:WO2011080341;   Patent:WO2012035057;   Patent:WO2012051692;   Reaxys:10206739 "Reaxys";   Wikipedia:Rivaroxaban


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rivaroxaban term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      application 19347
        pharmaceutical 19222
          drug 19222
            hematologic agent 4256
              anticoagulant 4051
                rivaroxaban 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic acid 17972
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                lactam 7819
                                                  rivaroxaban 8
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