Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:68584 term browser browse the term
Definition:A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Synonyms:related_synonym: D-23129;   Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate;   Formula=C16H18FN3O2;   InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21);   InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N;   N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester;   Potiga;   SMILES=CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N;   ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate;   retigabine
 xref: CAS:150812-12-7 "ChemIDplus";   CAS:150812-12-7 "KEGG COMPOUND";   Drug_Central:4181 "DrugCentral";   KEGG:C13826;   KEGG:D09569
 xref_mesh: MESH:C101866
 xref: PMID:22991134 "Europe PMC";   Patent:US2002015730;   Patent:US2002111379;   Patent:US2002183395;   Patent:US2012053238;   Patent:US5384330;   Patent:US6348486;   Patent:WO2007090409;   Patent:WO2011012659;   Reaxys:8072099 "Reaxys";   Wikipedia:Ezogabine

show annotations for term's descendants       view all columns           Sort by:
ezogabine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 JBrowse link 3 176,585,897 176,645,029 RGD:6480464
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 7 106,714,479 107,009,639 RGD:6480464
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 5 139,625,783 139,677,300 RGD:6480464
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      biological role 19693
        biophysical role 12254
          membrane transport modulator 12032
            potassium channel modulator 352
              ezogabine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    main group molecular entity 19628
                      s-block molecular entity 19393
                        hydrogen molecular entity 19382
                          hydrides 18296
                            inorganic hydride 17211
                              pnictogen hydride 17174
                                nitrogen hydride 17010
                                  azane 16703
                                    ammonia 16700
                                      organic amino compound 16699
                                        polyamine 8082
                                          triamine 28
                                            benzenetriamine 6
                                              benzene-1,2,4-triamine 6
                                                ezogabine 6
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.