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ONTOLOGY REPORT - ANNOTATIONS


Term:linagliptin
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Accession:CHEBI:68610 term browser browse the term
Definition:A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes.
Synonyms:exact_synonym: 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
 related_synonym: (R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione;   BI 1356;   Formula=C25H28N8O2;   InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1;   InChIKey=LTXREWYXXSTFRX-QGZVFWFLSA-N;   SMILES=CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1;   Tradjenta
 xref: CAS:668270-12-0 "ChemIDplus";   CAS:668270-12-0 "KEGG DRUG";   KEGG:D09566
 xref_mesh: MESH:D000069476
 xref: PDBeChem:356;   PMID:19476474 "Europe PMC";   PMID:19552619 "Europe PMC";   PMID:19732457 "Europe PMC";   PMID:19771584 "Europe PMC";   PMID:19777398 "Europe PMC";   PMID:19947894 "Europe PMC";   PMID:20086031 "Europe PMC";   PMID:20160157 "Europe PMC";   PMID:20497745 "Europe PMC";   PMID:20538719 "Europe PMC";   PMID:20637971 "Europe PMC";   PMID:20875371 "Europe PMC";   PMID:21053992 "Europe PMC";   PMID:21059094 "Europe PMC";   PMID:21084763 "Europe PMC";   PMID:21114605 "Europe PMC";   PMID:21205122 "Europe PMC";   PMID:21306414 "Europe PMC";   PMID:21340661 "Europe PMC";   PMID:21352464 "Europe PMC";   PMID:21410628 "Europe PMC";   PMID:21443284 "Europe PMC";   PMID:21543033 "Europe PMC";   PMID:21603986 "Europe PMC";   PMID:21642558 "Europe PMC";   PMID:21672124 "Europe PMC";   PMID:21680988 "Europe PMC";   PMID:21681003 "Europe PMC";   PMID:21701440 "Europe PMC";   PMID:21714581 "Europe PMC";   PMID:21723606 "Europe PMC";   PMID:21752782 "Europe PMC";   PMID:21781152 "Europe PMC";   PMID:21803422 "Europe PMC";   PMID:21883034 "Europe PMC";   PMID:21913883 "Europe PMC";   PMID:21916836 "Europe PMC";   PMID:22022857 "Europe PMC";   PMID:22143285 "Europe PMC";   PMID:22145698 "Europe PMC";   PMID:22149370 "Europe PMC";   PMID:22177783 "Europe PMC";   PMID:22198311 "Europe PMC";   PMID:22217485 "Europe PMC";   PMID:22234149 "Europe PMC";   PMID:22242621 "Europe PMC";   PMID:22268497 "Europe PMC";   PMID:22318932 "Europe PMC";   PMID:22340363 "Europe PMC";   PMID:22346314 "Europe PMC";   PMID:22356132 "Europe PMC";   PMID:22420306 "Europe PMC";   PMID:22440191 "Europe PMC";   PMID:22482239 "Europe PMC";   PMID:22493041 "Europe PMC";   PMID:22498683 "Europe PMC";   PMID:22541836 "Europe PMC";   PMID:22568694 "Europe PMC";   PMID:22587735 "Europe PMC";   PMID:22651241 "Europe PMC";   PMID:22691164 "Europe PMC";   PMID:22748821 "Europe PMC";   PMID:22761275 "Europe PMC";   PMID:22761701 "Europe PMC";   PMID:22804249 "Europe PMC";   PMID:22816729 "Europe PMC";   PMID:22879795 "Europe PMC";   PMID:22913735 "Europe PMC";   PMID:22926098 "Europe PMC";   PMID:22939034 "Europe PMC";   PMID:22974280 "Europe PMC";   PMID:22986920 "Europe PMC";   PMID:22997980 "Europe PMC";   PMID:23033241 "Europe PMC";   Patent:EP1852108;   Patent:EP246874;   Patent:US2007259900;   Patent:US2012165525;   Patent:WO2004018468;   Patent:WO2006048427;   Patent:WO2009022008;   Patent:WO2010072776;   Reaxys:11300181 "Reaxys";   Wikipedia:Linagliptin


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linagliptin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dpp4 dipeptidylpeptidase 4 JBrowse link 3 48,291,055 48,372,672 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Olig2 oligodendrocyte transcription factor 2 JBrowse link 11 31,389,514 31,392,890 RGD:6480464
G Plp1 proteolipid protein 1 JBrowse link X 107,494,326 107,511,355 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      application 19350
        pharmaceutical 19224
          drug 19224
            hypoglycemic agent 3991
              linagliptin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic molecule 19434
                              organic cyclic compound 19201
                                organic heterocyclic compound 18270
                                  organic heteropolycyclic compound 17577
                                    organic heterobicyclic compound 16245
                                      imidazopyrimidine 5417
                                        purines 5415
                                          aminopurine 4374
                                            2-aminopurines 4000
                                              guanine 3964
                                                xanthine 3883
                                                  7H-xanthine 3100
                                                    linagliptin 14
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