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ONTOLOGY REPORT - ANNOTATIONS


Term:abiraterone
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Accession:CHEBI:68642 term browser browse the term
Definition:A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.
Synonyms:exact_synonym: 17-(pyridin-3-yl)androsta-5,16-dien-3beta-ol
 related_synonym: (3beta)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol;   17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;   Formula=C24H31NO;   InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1;   InChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=CC[C@@]21[H])c1cccnc1
 xref: CAS:154229-19-3 "ChemIDplus"
 xref_mesh: MESH:C089740
 xref: PDBeChem:AER;   PMID:21093995 "Europe PMC";   PMID:21239011 "Europe PMC";   PMID:21242338 "Europe PMC";   PMID:21326154 "Europe PMC";   PMID:21612468 "Europe PMC";   PMID:21729712 "Europe PMC";   PMID:21743442 "Europe PMC";   PMID:21807635 "Europe PMC";   PMID:21808270 "Europe PMC";   PMID:21857690 "Europe PMC";   PMID:21864180 "Europe PMC";   PMID:21864181 "Europe PMC";   PMID:21864182 "Europe PMC";   PMID:21878199 "Europe PMC";   PMID:22002259 "Europe PMC";   PMID:22170708 "Europe PMC";   PMID:22266943 "Europe PMC";   PMID:22331349 "Europe PMC";   PMID:22373884 "Europe PMC";   PMID:22402426 "Europe PMC";   PMID:22411952 "Europe PMC";   PMID:22451619 "Europe PMC";   PMID:22500680 "Europe PMC";   PMID:22611169 "Europe PMC";   PMID:22753664 "Europe PMC";   PMID:22763809 "Europe PMC";   PMID:22822591 "Europe PMC";   PMID:22915660 "Europe PMC";   PMID:23024987 "Europe PMC";   Patent:EP1336602;   Patent:US2011034428;   Patent:US5604213;   Patent:WO2012083112;   Reaxys:7309269 "Reaxys";   Wikipedia:Abiraterone


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abiraterone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        pharmaceutical 19211
          drug 19211
            antineoplastic agent 16895
              abiraterone 6
                abiraterone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic molecule 19418
                              organic cyclic compound 19189
                                organic polycyclic compound 16031
                                  steroid 12785
                                    hydroxy steroid 12372
                                      3-hydroxy steroid 10001
                                        sterol 411
                                          3beta-sterol 405
                                            abiraterone 6
                                              abiraterone acetate 0
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