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Accession:CHEBI:68850 term browser browse the term
Definition:A benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) for treatment of hypertension.
Synonyms:exact_synonym: 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
 related_synonym: Formula=C25H20N4O5;   InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32);   InChIKey=KGSXMPPBFPAXLY-UHFFFAOYSA-N;   SMILES=CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1;   TAK-536
 xref: CAS:147403-03-0 "ChemIDplus";   CAS:147403-03-0 "KEGG DRUG";   KEGG:D08864
 xref_mesh: MESH:C521273
 xref: PMID:21749604 "Europe PMC";   PMID:21983318 "Europe PMC";   PMID:21986624 "Europe PMC";   PMID:22278628 "Europe PMC";   PMID:22365278 "Europe PMC";   PMID:22399858 "Europe PMC";   PMID:22661897 "Europe PMC";   PMID:22728984 "Europe PMC";   PMID:22745562 "Europe PMC";   PMID:22975662 "Europe PMC";   PMID:23012812 "Europe PMC";   PMID:23034464 "Europe PMC";   PMID:23051655 "Europe PMC";   Patent:EP1787647;   Patent:US2005187269;   Patent:WO2012107814;   Reaxys:7673311 "Reaxys";   Wikipedia:Azilsartan

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azilsartan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      application 19350
        pharmaceutical 19224
          drug 19224
            cardiovascular drug 7575
              antihypertensive agent 1645
                azilsartan 3
                  azilsartan medoxomil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic group 18426
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18306
                                    carbonyl compound 18306
                                      carboxylic acid 17973
                                        monocarboxylic acid 17268
                                          benzimidazolecarboxylic acid 73
                                            azilsartan 3
                                              azilsartan medoxomil 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.