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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6alpha-methylprednisolone
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Accession:CHEBI:6888 term browser browse the term
Definition:The 6alpha-stereoisomer of 6-methylprednisolone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione;   1-dehydro-6alpha-methylhydrocortisone;   6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione;   Delta(1)-6alpha-methylhydrocortisone;   Formula=C22H30O5;   InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1;   InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N;   Medrate;   Medrol;   Medrone;   Methylprednisolon;   SMILES=C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12;   Solomet;   Urbason;   methylprednisolone;   methylprednisolonum;   metilprednisolona
 xref: Beilstein:2340300;   CAS:83-43-2;   DrugBank:DB00959;   Drug_Central:1768;   HMDB:HMDB0015094;   KEGG:D00407
 xref_mesh: MESH:D008775
 xref: PMID:25232411;   Patent:US2897218;   Patent:US3053832;   Reaxys:2340300;   VSDB:1936;   Wikipedia:Methylprednisolone


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6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein
CTD PMID:16932953, PMID:22079615, PMID:22464980 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]
CTD PMID:15187100, PMID:30878453 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases secretion
EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ar androgen receptor multiple interactions ISO Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061, PMID:26093215 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases secretion
multiple interactions
EXP Methylprednisolone results in decreased secretion of BGLAP protein
[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]
CTD PMID:30291735 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Capn2 calpain 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein
CTD PMID:1942778, PMID:30291735 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Clgn calmegin decreases expression ISO Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA
CTD PMID:19192274, PMID:26093215 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]
CTD PMID:21931329 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Methylprednisolone results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dmd dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F8 coagulation factor VIII increases expression ISO Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein]
CTD PMID:21931329 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fcer2 Fc fragment of IgE receptor II multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FOXO1 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]
CTD PMID:21931329 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein
CTD PMID:1942778 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsdme gasdermin E decreases expression ISO Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
ISO [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein
CTD PMID:15329590 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Il10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein
CTD PMID:7988651, PMID:11997017 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein
CTD PMID:19192274, PMID:26093215 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mbp myelin basic protein decreases expression ISO Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
CTD PMID:26093215, PMID:28557239, PMID:30891624 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Methylprednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:70,821,904...70,824,085
Ensembl chr 7:70,821,957...70,824,085
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nid2 nidogen 2 increases expression ISO Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,893,999...4,951,893
Ensembl chr15:4,894,213...4,951,917
JBrowse link
G Nmb neuromedin B decreases expression ISO Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity
multiple interactions
EXP Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:235222, PMID:6277579 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sms spermine synthase decreases expression ISO Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
increases activity
EXP
ISO
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA
Methylprednisolone results in increased activity of SOD2 protein
CTD PMID:1942778, PMID:19192274 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Sts steroid sulfatase increases expression ISO Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
Methylprednisolone results in decreased expression of TNF protein
CTD PMID:8384958, PMID:26093215, PMID:28557239 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein]
CTD PMID:21931329 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Vwf von Willebrand factor decreases expression
increases expression
ISO Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein
CTD PMID:7491699, PMID:20405515 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        xenobiotic 18413
          6alpha-methylprednisolone 126
            methylprednisolone 21-suleptanic acid ester 0
            methylprednisolone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxo steroid 9283
                                          3-oxo steroid 8811
                                            3-oxo-Delta(4) steroid 7939
                                              progesterone 2709
                                                Delta(1)-progesterone 236
                                                  prednisolone 231
                                                    6-methylprednisolone 126
                                                      6alpha-methylprednisolone 126
                                                        methylprednisolone 21-suleptanic acid ester 0
                                                        methylprednisolone acetate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.