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ONTOLOGY REPORT - ANNOTATIONS


Term:6alpha-methylprednisolone
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Accession:CHEBI:6888 term browser browse the term
Definition:The 6alpha-stereoisomer of 6-methylprednisolone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione;   1-dehydro-6alpha-methylhydrocortisone;   6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione;   Delta(1)-6alpha-methylhydrocortisone;   Formula=C22H30O5;   InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1;   InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N;   Medrate;   Medrol;   Medrone;   Methylprednisolon;   SMILES=C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12;   Solomet;   Urbason;   methylprednisolone;   methylprednisolonum;   metilprednisolona
 xref: Beilstein:2340300 "Beilstein";   CAS:83-43-2 "ChemIDplus";   CAS:83-43-2 "NIST Chemistry WebBook";   DrugBank:DB00959;   Drug_Central:1768 "DrugCentral";   HMDB:HMDB0015094;   KEGG:D00407
 xref_mesh: MESH:D008775
 xref: PMID:25232411 "Europe PMC";   Patent:US2897218;   Patent:US3053832;   Reaxys:2340300 "Reaxys";   VSDB:1936;   Wikipedia:Methylprednisolone


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6alpha-methylprednisolone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Ackr3 atypical chemokine receptor 3 JBrowse link 9 97,355,881 97,367,455 RGD:6480464
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Amigo2 adhesion molecule with Ig like domain 2 JBrowse link 7 138,704,124 138,707,221 RGD:6480464
G Antxr1 ANTXR cell adhesion molecule 1 JBrowse link 4 118,946,267 119,131,202 RGD:6480464
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:6480464
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6480464
G Bst2 bone marrow stromal cell antigen 2 JBrowse link 16 19,938,781 19,942,353 RGD:6480464
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Ccn5 cellular communication network factor 5 JBrowse link 3 160,207,969 160,219,316 RGD:6480464
G Clgn calmegin JBrowse link 19 24,545,257 24,578,527 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:6480464
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:6480464
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:6480464
G Fbln1 fibulin 1 JBrowse link 7 126,096,793 126,176,468 RGD:6480464
G Fbxo32 F-box protein 32 JBrowse link 7 98,065,664 98,098,071 RGD:6480464
G Fcer2 Fc fragment of IgE receptor II JBrowse link 12 2,233,772 2,245,324 RGD:6480464
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6480464
G Gbp1 guanylate binding protein 1 JBrowse link 2 248,343,334 248,423,402 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gpm6b glycoprotein m6b JBrowse link X 29,604,607 29,751,174 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Gsdme gasdermin E JBrowse link 4 79,934,075 79,999,678 RGD:6480464
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 JBrowse link 4 88,606,851 88,649,424 RGD:6480464
G Hilpda hypoxia inducible lipid droplet-associated JBrowse link 4 56,547,600 56,550,584 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6480464
G Htr3a 5-hydroxytryptamine receptor 3A JBrowse link 8 53,211,436 53,223,878 RGD:6480464
G Id3 inhibitor of DNA binding 3, HLH protein JBrowse link 5 154,489,603 154,491,172 RGD:6480464
G Ifi27 interferon, alpha-inducible protein 27 JBrowse link 6 127,327,959 127,334,430 RGD:6480464
G Ifi35 interferon-induced protein 35 JBrowse link 10 89,358,376 89,366,628 RGD:6480464
G Ifi44 interferon-induced protein 44 JBrowse link 2 256,897,765 256,915,591 RGD:6480464
G Ifi44l interferon-induced protein 44-like JBrowse link 2 256,948,722 256,979,573 RGD:6480464
G Ifih1 interferon induced with helicase C domain 1 JBrowse link 3 48,557,696 48,604,097 RGD:6480464
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 JBrowse link 1 252,906,234 252,911,377 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:6480464
G Isg15 ISG15 ubiquitin-like modifier JBrowse link 5 173,624,862 173,629,124 RGD:6480464
G Isg20 interferon stimulated exonuclease gene 20 JBrowse link 1 140,602,553 140,608,892 RGD:6480464
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6480464
G Lamb1 laminin subunit beta 1 JBrowse link 6 50,528,796 50,596,593 RGD:6480464
G Lamb2 laminin subunit beta 2 JBrowse link 8 117,268,335 117,280,517 RGD:6480464
G Lamb3 laminin subunit beta 3 JBrowse link 13 112,031,614 112,073,187 RGD:6480464
G Ly6e lymphocyte antigen 6 family member E JBrowse link 7 116,355,426 116,359,862 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Marcks myristoylated alanine rich protein kinase C substrate JBrowse link 20 42,966,140 42,971,838 RGD:6480464
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:6480464
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6480464
G Mmp10 matrix metallopeptidase 10 JBrowse link 8 5,734,348 5,742,243 RGD:6480464
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Mx2 MX dynamin like GTPase 2 JBrowse link 11 38,035,306 38,066,185 RGD:6480464
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 JBrowse link 7 70,821,904 70,824,085 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nid2 nidogen 2 JBrowse link 15 4,893,999 4,951,893 RGD:6480464
G Nmb neuromedin B JBrowse link 1 142,721,263 142,724,646 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:6480464
G Oas1a 2'-5' oligoadenylate synthetase 1A JBrowse link 12 41,200,680 41,211,393 RGD:6480464
G Oas3 2'-5'-oligoadenylate synthetase 3 JBrowse link 12 41,313,081 41,368,217 RGD:6480464
G Oasl 2'-5'-oligoadenylate synthetase-like JBrowse link 12 47,444,138 47,456,680 RGD:6480464
G Phgdh phosphoglycerate dehydrogenase JBrowse link 2 200,484,245 200,513,564 RGD:6480464
G Pla1a phospholipase A1 member A JBrowse link 11 64,882,024 64,919,714 RGD:6480464
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6480464
G Plpp3 phospholipid phosphatase 3 JBrowse link 5 124,690,214 124,765,499 RGD:6480464
G Prelp proline and arginine rich end leucine rich repeat protein JBrowse link 13 50,749,526 50,773,934 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:6480464
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:6480464
G Rnf19b ring finger protein 19B JBrowse link 5 147,246,032 147,270,892 RGD:6480464
G Rsad2 radical S-adenosyl methionine domain containing 2 JBrowse link 6 45,655,947 45,669,083 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Slc43a3 solute carrier family 43, member 3 JBrowse link 3 72,328,912 72,351,039 RGD:6480464
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:6480464
G Sms spermine synthase JBrowse link X 40,363,646 40,415,110 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:6480464
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfaip2 TNF alpha induced protein 2 JBrowse link 6 135,890,869 135,903,647 RGD:6480464
G Trim63 tripartite motif containing 63 JBrowse link 5 152,533,362 152,547,138 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19617
    role 19560
      biological role 19553
        xenobiotic 18180
          6alpha-methylprednisolone 125
            methylprednisolone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19617
    subatomic particle 19613
      composite particle 19613
        hadron 19613
          baryon 19613
            nucleon 19613
              atomic nucleus 19613
                atom 19613
                  main group element atom 19491
                    p-block element atom 19491
                      carbon group element atom 19363
                        carbon atom 19355
                          organic molecular entity 19355
                            organic group 18311
                              organic divalent group 18301
                                organodiyl group 18301
                                  carbonyl group 18186
                                    carbonyl compound 18186
                                      ketone 15648
                                        oxo steroid 8750
                                          3-oxo steroid 8240
                                            3-oxo-Delta(4) steroid 7495
                                              progesterone 2689
                                                Delta(1)-progesterone 235
                                                  prednisolone 230
                                                    6-methylprednisolone 125
                                                      6alpha-methylprednisolone 125
                                                        methylprednisolone acetate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.