Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:latrunculin A
go back to main search page
Accession:CHEBI:69136 term browser browse the term
Definition:A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.
Synonyms:related_synonym: (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one;   Formula=C22H31NO5S;   InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1;   InChIKey=DDVBPZROPPMBLW-IZGXTMSKSA-N;   LAT-A;   LatA;   NSC 613011;   SMILES=[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/C=C/CC\\C(C)=C/C(=O)O2)O1
 alt_id: CHEBI:43626
 xref: CAS:76343-93-6 "ChemIDplus"
 xref_mesh: MESH:C037067
 xref: PDBeChem:LAR;   PMID:10859320 "Europe PMC";   PMID:12087066 "Europe PMC";   PMID:17897856 "Europe PMC";   PMID:19528469 "Europe PMC";   PMID:20677927 "Europe PMC";   PMID:22492972 "Europe PMC";   PMID:22498812 "Europe PMC";   PMID:3200109 "Europe PMC";   PMID:3556584 "Europe PMC";   PMID:9250716 "Europe PMC";   Reaxys:4239363 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:
latrunculin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6480464
G Diaph1 diaphanous-related formin 1 JBrowse link 18 30,972,907 31,071,371 RGD:6480464
G Fscn1 fascin actin-bundling protein 1 JBrowse link 12 13,655,459 13,668,595 RGD:6480464
G Fscn2 fascin actin-bundling protein 2, retinal JBrowse link 10 109,528,307 109,540,675 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:6480464
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        biochemical role 19192
          metabolite 19164
            latrunculin A 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic ester 13974
                                        lactone 5871
                                          macrocyclic lactone 1557
                                            macrolide 1498
                                              latrunculin A 10
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.