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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:brazilein
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Accession:CHEBI:69196 term browser browse the term
Definition:A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).
Synonyms:exact_synonym: (6aS)-3,6a,10-trihydroxy-6a,7-dihydrobenzo[b]indeno[1,2-d]pyran-9(6H)-one
 related_synonym: Formula=C16H12O5;   InChI=1S/C16H12O5/c17-9-1-2-10-14(4-9)21-7-16(20)6-8-3-12(18)13(19)5-11(8)15(10)16/h1-5,17,19-20H,6-7H2/t16-/m1/s1;   InChIKey=MLWIYODOURBGPI-MRXNPFEDSA-N;   SMILES=C=12C(=CC(O)=CC1)OC[C@]3(C2=C4C(C3)=CC(=O)C(=C4)O)O
 xref_mesh: MESH:C050295
 xref: PMID:16319518;   PMID:16428078;   PMID:17504570;   PMID:23554834;   PMID:23657435;   PMID:23707804;   PMID:23948132;   PMID:24050687;   PMID:24703330;   PMID:25233024;   PMID:25275506;   PMID:25893688;   PMID:26254246;   Reaxys:8071909


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brazilein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 decreases expression ISO brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein CTD PMID:23948132 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO brazilein results in decreased expression of CTNNB1 protein CTD PMID:23948132 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO brazilein results in decreased expression of GSK3B protein modified form CTD PMID:23948132 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA
CTD PMID:23707804 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:23707804 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO brazilein results in decreased expression of RELA protein CTD PMID:23707804 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        antioxidant 14226
          brazilein 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterotetracyclic compound 4654
                                      brazilein 6
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