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ONTOLOGY REPORT - ANNOTATIONS


Term:microcystin-LR
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Accession:CHEBI:6925 term browser browse the term
Definition:A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Synonyms:exact_synonym: cyclo[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanyl]
 related_synonym: 1,7-anhydro[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanine];   Formula=C49H74N10O12;   InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1;   InChIKey=ZYZCGGRZINLQBL-GWRQVWKTSA-N;   Microcystis aeruginosa toxin;   SMILES=C([C@H](OC)[C@@H](C)/C=C(\\C)/C=C/[C@@]1(NC([C@H](CCCNC(=N)N)NC([C@H]([C@H](C(O)=O)NC([C@H](CC(C)C)NC([C@@H](C)NC(C(N(C(CC[C@@H](NC([C@H]1C)=O)C(O)=O)=O)C)=C)=O)=O)=O)C)=O)=O)[H])C=2C=CC=CC2;   cyanoginosin LR;   cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl];   toxin-LR
 xref: Beilstein:4779759 "ChemIDplus";   CAS:101043-37-2 "ChemIDplus";   CAS:101043-37-2 "KEGG COMPOUND";   KEGG:C05371
 xref_mesh: MESH:C057862
 xref: PMID:10903983 "Europe PMC";   PMID:17125460 "Europe PMC";   PMID:18246549 "Europe PMC";   PMID:21489775 "Europe PMC";   PMID:22071605 "Europe PMC";   PMID:22301162 "Europe PMC";   PMID:22837451 "Europe PMC";   PMID:22956115 "Europe PMC";   PMID:23131420 "Europe PMC";   PMID:23506857 "Europe PMC";   PMID:23586662 "Europe PMC";   PMID:23999063 "Europe PMC";   PMID:24268348 "Europe PMC";   PMID:24280256 "Europe PMC";   PMID:24318164 "Europe PMC";   PMID:24462717 "Europe PMC";   PMID:24631598 "Europe PMC";   PMID:28648727 "Europe PMC";   Reaxys:4779759 "Reaxys";   Wikipedia:Microcystin-LR


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microcystin-LR term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca8 ATP binding cassette subfamily A member 8 JBrowse link 10 98,236,919 98,308,288 RGD:6480464
G Abcb10 ATP binding cassette subfamily B member 10 JBrowse link 19 56,742,809 56,772,904 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:6480464
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 8 127,836,235 127,845,296 RGD:6480464
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Acad10 acyl-CoA dehydrogenase family, member 10 JBrowse link 12 40,417,918 40,460,562 RGD:6480464
G Acad11 acyl-CoA dehydrogenase family, member 11 JBrowse link 8 112,594,758 112,676,275 RGD:6480464
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:6480464
G Acadm acyl-CoA dehydrogenase medium chain JBrowse link 2 260,124,418 260,148,589 RGD:6480464
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:6480464
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:6480464
G Acox3 acyl-CoA oxidase 3, pristanoyl JBrowse link 14 80,313,202 80,358,115 RGD:6480464
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:6480464
G Afm afamin JBrowse link 14 19,078,678 19,132,212 RGD:6480464
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 JBrowse link 4 123,516,553 123,564,067 RGD:6480464
G Alpi alkaline phosphatase, intestinal JBrowse link 9 94,197,616 94,201,910 RGD:6480464
G Alyref Aly/REF export factor JBrowse link 10 109,768,593 109,774,639 RGD:6480464
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:6480464
G Anxa4 annexin A4 JBrowse link 4 118,538,775 118,595,591 RGD:6480464
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:6480464
G Anxa7 annexin A7 JBrowse link 15 4,254,470 4,281,296 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:6480464
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Ass1 argininosuccinate synthase 1 JBrowse link 3 10,327,411 10,375,847 RGD:6480464
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:6480464
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Blvrb biliverdin reductase B JBrowse link 1 84,256,063 84,273,726 RGD:6480464
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:6480464
G Bsg basigin (Ok blood group) JBrowse link 7 12,875,536 12,882,753 RGD:6480464
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:6480464
G Cables1 Cdk5 and Abl enzyme substrate 1 JBrowse link 18 3,317,724 3,421,721 RGD:6480464
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6480464
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6480464
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 4 145,289,300 145,300,146 RGD:6480464
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:6480464
G Capns1 calpain, small subunit 1 JBrowse link 1 91,058,528 91,064,880 RGD:6480464
G Capzb capping actin protein of muscle Z-line subunit beta JBrowse link 5 157,642,742 157,742,487 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:6480464
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:6480464
G Ccdc180 coiled-coil domain containing 180 JBrowse link 5 61,467,799 61,542,675 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnf cyclin F JBrowse link 10 13,594,687 13,619,935 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:6480464
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:6480464
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6480464
G Coro1c coronin 1C JBrowse link 12 48,481,741 48,554,054 RGD:6480464
G Creb3 cAMP responsive element binding protein 3 JBrowse link 5 59,063,532 59,068,196 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cspg4 chondroitin sulfate proteoglycan 4 JBrowse link 8 61,532,465 61,567,510 RGD:6480464
G Cstb cystatin B JBrowse link 20 10,966,357 10,968,399 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:6480464
G Ctsz cathepsin Z JBrowse link 3 172,527,107 172,537,877 RGD:6480464
G Cttn cortactin JBrowse link 1
1
217,602,698
215,255,385
217,638,196
215,290,882
RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 JBrowse link 8 130,548,418 130,550,388 RGD:6480464
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Ddit4l DNA-damage-inducible transcript 4-like JBrowse link 2 242,882,219 242,885,088 RGD:6480464
G Decr2 2,4-dienoyl-CoA reductase 2 JBrowse link 10 15,451,850 15,460,227 RGD:6480464
G Dgat1 diacylglycerol O-acyltransferase 1 JBrowse link 7 117,566,363 117,576,735 RGD:6480464
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:6480464
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:6480464
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6480464
G Eef1d eukaryotic translation elongation factor 1 delta JBrowse link 7 116,928,264 116,942,981 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eif4a3 eukaryotic translation initiation factor 4A3 JBrowse link 10 108,415,201 108,425,195 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Etv5 ETS variant transcription factor 5 JBrowse link 11 82,194,657 82,252,145 RGD:6480464
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6480464
G Fads1 fatty acid desaturase 1 JBrowse link 1 226,234,034 226,249,118 RGD:6480464
G Fads2 fatty acid desaturase 2 JBrowse link 1 225,906,582 226,152,568 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fgf13 fibroblast growth factor 13 JBrowse link X 142,053,648 142,589,274 RGD:6480464
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:6480464
G Fhdc1 FH2 domain containing 1 JBrowse link 2 183,450,608 183,487,820 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Ftl1 ferritin light chain 1 JBrowse link 1 101,448,190 101,450,034 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6480464
G Gas1 growth arrest-specific 1 JBrowse link 17 4,846,116 4,849,350 RGD:6480464
G Gbp5 guanylate binding protein 5 JBrowse link 2 248,178,441 248,196,873 RGD:6480464
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:6480464
G Gipc2 GIPC PDZ domain containing family, member 2 JBrowse link 2 257,293,161 257,377,982 RGD:6480464
G Glrx3 glutaredoxin 3 JBrowse link 1 209,768,696 209,799,912 RGD:6480464
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:6480464
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6480464
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial JBrowse link 1 275,843,823 275,906,880 RGD:6480464
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6480464
G Gpx2 glutathione peroxidase 2 JBrowse link 6 99,839,960 99,843,245 RGD:6480464
G Gpx3 glutathione peroxidase 3 JBrowse link 10 40,247,436 40,255,423 RGD:6480464
G Gpx4 glutathione peroxidase 4 JBrowse link 7 12,516,357 12,519,154 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gsta6 glutathione S-transferase alpha 6 JBrowse link 9 27,475,273 27,533,939 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Gstm4 glutathione S-transferase mu 4 JBrowse link 2 210,834,013 210,839,242 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 2 210,685,338 210,688,133 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:6480464
G Gtpbp4 GTP binding protein 4 JBrowse link 17 63,111,086 63,145,618 RGD:6480464
G Gys1 glycogen synthase 1 JBrowse link 1 101,427,195 101,447,092 RGD:6480464
G H2bc1 H2B clustered histone 1 JBrowse link 17 43,423,111 43,423,580 RGD:6480464
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6480464
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta JBrowse link 6 27,555,408 27,589,539 RGD:6480464
G Hephl1 hephaestin-like 1 JBrowse link 8 13,614,800 13,680,870 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:6480464
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:6480464
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:6480464
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6480464
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 JBrowse link 9 71,882,108 71,911,645 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Igbp1 immunoglobulin binding protein 1 JBrowse link X 70,322,764 70,345,005 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6480464
G Igkc immunoglobulin kappa constant RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Inmt indolethylamine N-methyltransferase JBrowse link 4 85,381,907 85,386,203 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:6480464
G Ints2 integrator complex subunit 2 JBrowse link 10 73,632,805 73,690,952 RGD:6480464
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6480464
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6480464
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Kif5b kinesin family member 5B JBrowse link 17 54,181,416 54,219,048 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:6480464
G Kpna4 karyopherin subunit alpha 4 JBrowse link 2 165,684,345 165,739,874 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Krt8 keratin 8 JBrowse link 7 143,596,511 143,603,745 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Lgals1 galectin 1 JBrowse link 7 120,153,184 120,156,290 RGD:6480464
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6480464
G Lgals3bp galectin 3 binding protein JBrowse link 10 107,415,334 107,424,672 RGD:6480464
G Lpin2 lipin 2 JBrowse link 9 119,517,101 119,591,533 RGD:6480464
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:6480464
G Lypla2 lysophospholipase 2 JBrowse link 5 154,315,033 154,319,629 RGD:6480464
G Maged1 MAGE family member D1 JBrowse link X 63,803,194 63,809,715 RGD:6480464
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Mcat malonyl-CoA-acyl carrier protein transacylase JBrowse link 7 124,412,762 124,424,966 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6480464
G Mfge8 milk fat globule-EGF factor 8 protein JBrowse link 1 140,845,478 140,860,882 RGD:6480464
G Mir100 microRNA 100 JBrowse link 8 45,746,948 45,747,027 RGD:6480464
G Mir137 microRNA 137 JBrowse link 2 221,658,106 221,658,207 RGD:6480464
G Mir181a2 microRNA 181a-2 JBrowse link 3 23,150,352 23,150,468 RGD:6480464
G Mir19a microRNA 19a JBrowse link 15 100,180,162 100,180,243 RGD:6480464
G Mir204 microRNA 204 JBrowse link 1 240,403,000 240,403,109 RGD:6480464
G Mir27a microRNA 27a JBrowse link 19 25,318,736 25,318,822 RGD:6480464
G Mir30b microRNA 30b JBrowse link 7 109,282,662 109,282,747 RGD:6480464
G Mir31 microRNA 31 JBrowse link 5 107,206,515 107,206,620 RGD:6480464
G Mir320a microRNA 320a JBrowse link 15 52,134,276 52,134,357 RGD:6480464
G Mir33 microRNA 33 JBrowse link 7 123,431,612 123,431,680 RGD:6480464
G Mir331 microRNA 331 JBrowse link 7 34,881,095 34,881,190 RGD:6480464
G Mir342 microRNA 342 JBrowse link 6 132,561,169 132,561,267 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mmgt1 membrane magnesium transporter 1 JBrowse link X 158,966,694 158,978,995 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 8 5,522,739 5,533,018 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mrps7 mitochondrial ribosomal protein S7 JBrowse link 10 104,155,805 104,158,840 RGD:6480464
G Ms4a7 membrane spanning 4-domains A7 JBrowse link 1 227,490,777 227,506,819 RGD:6480464
G Msn moesin JBrowse link X 65,226,834 65,294,192 RGD:6480464
G Msrb1 methionine sulfoxide reductase B1 JBrowse link 10 14,105,750 14,111,463 RGD:6480464
G Mt-atp6 mitochondrially encoded ATP synthase 6 JBrowse link MT 7,919 8,599 RGD:6480464
G Mt-atp8 mitochondrially encoded ATP synthase 8 JBrowse link MT 7,758 7,961 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Mt-co2 mitochondrially encoded cytochrome c oxidase II JBrowse link MT 7,006 7,689 RGD:6480464
G Mt-co3 mitochondrially encoded cytochrome c oxidase III JBrowse link MT 8,599 9,382 RGD:6480464
G Mt-nd1 mitochondrially encoded NADH dehydrogenase 1 JBrowse link MT 2,740 3,694 RGD:6480464
G Mt-nd3 mitochondrially encoded NADH dehydrogenase 3 JBrowse link MT 9,451 9,798 RGD:6480464
G Mt-nd6 mitochondrially encoded NADH dehydrogenase 6 JBrowse link MT 13,543 14,061 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Mttp microsomal triglyceride transfer protein JBrowse link 2 243,366,181 243,407,608 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Mylk3 myosin light chain kinase 3 JBrowse link 19 27,388,163 27,442,451 RGD:6480464
G Naip6 NLR family, apoptosis inhibitory protein 6 JBrowse link 2 30,377,505 30,418,578 RGD:6480464
G Nalcn sodium leak channel, non-selective JBrowse link 15 109,734,092 110,046,729 RGD:6480464
G Necap1 NECAP endocytosis associated 1 JBrowse link 4 155,709,712 155,724,801 RGD:6480464
G Net1 neuroepithelial cell transforming 1 JBrowse link 17 69,991,786 70,020,977 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6480464
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine JBrowse link 10 109,788,348 109,795,743 RGD:6480464
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6480464
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:6480464
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6480464
G Pdzk1 PDZ domain containing 1 JBrowse link 2 198,965,685 198,999,323 RGD:6480464
G Pepd peptidase D JBrowse link 1 90,820,670 91,285,128 RGD:6480464
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:6480464
G Pfn2 profilin 2 JBrowse link 2 147,953,858 147,959,692 RGD:6480464
G Pgd phosphogluconate dehydrogenase JBrowse link 5 165,966,128 165,982,327 RGD:6480464
G Pigr polymeric immunoglobulin receptor JBrowse link 13 47,564,176 47,592,093 RGD:6480464
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6480464
G Pitrm1 pitrilysin metallopeptidase 1 JBrowse link 17 68,477,423 68,509,113 RGD:6480464
G Plin3 perilipin 3 JBrowse link 9 10,769,739 10,781,659 RGD:6480464
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:6480464
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:6480464
G Pmpcb peptidase, mitochondrial processing subunit beta JBrowse link 4 9,908,838 9,921,615 RGD:6480464
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6480464
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:6480464
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:6480464
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta JBrowse link 6 51,265,509 51,356,383 RGD:6480464
G Prkd3 protein kinase D3 JBrowse link 6 1,546,018 1,622,232 RGD:6480464
G Prune1 prune exopolyphosphatase 1 JBrowse link 2 196,427,714 196,457,105 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:6480464
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:6480464
G Rbm39 RNA binding motif protein 39 JBrowse link 3 151,691,498 151,724,723 RGD:6480464
G Rdx radixin JBrowse link 8 56,570,728 56,612,851 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Rhoc ras homolog family member C JBrowse link 2 207,271,692 207,278,010 RGD:6480464
G Rhoq ras homolog family member Q JBrowse link 6 10,533,151 10,568,582 RGD:6480464
G Rit1 Ras-like without CAAX 1 JBrowse link 2 188,087,486 188,099,444 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G RT1-A2 RT1 class Ia, locus A2 JBrowse link 20 5,374,990 5,378,536 RGD:6480464
G S100a11 S100 calcium binding protein A11 JBrowse link 2 193,863,185 193,868,646 RGD:6480464
G Serpinb6a serpin family B member 6A JBrowse link 17 32,154,747 32,209,598 RGD:6480464
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6480464
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Slco3a1 solute carrier organic anion transporter family, member 3a1 JBrowse link 1 135,790,854 136,073,640 RGD:6480464
G Slco6b1 solute carrier organic anion transporter family member 6B1 JBrowse link 9 104,388,232 104,468,005 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6480464
G Smoc2 SPARC related modular calcium binding 2 JBrowse link 1 56,242,289 56,374,106 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Spint2 serine peptidase inhibitor, Kunitz type, 2 JBrowse link 1 87,199,373 87,221,826 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Suclg2 succinate-CoA ligase GDP-forming subunit beta JBrowse link 4 127,552,100 127,824,970 RGD:6480464
G Sult1b1 sulfotransferase family 1B member 1 JBrowse link 14 22,142,412 22,155,246 RGD:6480464
G Syne1 spectrin repeat containing nuclear envelope protein 1 JBrowse link 1
1
41,608,287
41,844,840
41,763,591
42,086,662
RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6480464
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Thrsp thyroid hormone responsive JBrowse link 1 162,381,251 162,385,575 RGD:6480464
G Tjp1 tight junction protein 1 JBrowse link 1 126,146,489 126,515,359 RGD:6480464
G Tmsb10 thymosin, beta 10 JBrowse link 4 100,882,216 100,883,303 RGD:6480464
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf12a TNF receptor superfamily member 12A JBrowse link 10 12,995,904 12,997,930 RGD:6480464
G Tnp2 transition protein 2 JBrowse link 10 4,953,898 4,954,626 RGD:6480464
G Tnpo1 transportin 1 JBrowse link 2 29,056,219 29,126,882 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tpm1 tropomyosin 1 JBrowse link 8 72,814,737 72,841,496 RGD:6480464
G Treh trehalase JBrowse link 8 48,983,802 48,998,072 RGD:6480464
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:6480464
G Trrap transformation/transcription domain-associated protein JBrowse link 12 11,537,950 11,627,563 RGD:6480464
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:6480464
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:6480464
G Tub TUB bipartite transcription factor JBrowse link 1 173,550,929 173,629,550 RGD:6480464
G Txndc12 thioredoxin domain containing 12 JBrowse link 5 128,450,830 128,475,858 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:6480464
G Uba2 ubiquitin-like modifier activating enzyme 2 JBrowse link 1 90,010,681 90,035,522 RGD:6480464
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:6480464
G Ugp2 UDP-glucose pyrophosphorylase 2 JBrowse link 14 106,208,174 106,249,322 RGD:6480464
G Upp2 uridine phosphorylase 2 JBrowse link 3 44,806,106 44,846,464 RGD:6480464
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:6480464
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 1 80,170,608 80,185,882 RGD:6480464
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:6480464
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:6480464
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6480464
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6480464
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6480464
G Zfp704 zinc finger protein 704 JBrowse link 2 94,377,059 94,559,838 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        xenobiotic 18261
          microcystin-LR 352
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        carboacyl group 16948
                                          univalent carboacyl group 16948
                                            carbamoyl group 16630
                                              carboxamide 16630
                                                peptide 9315
                                                  cyclic peptide 8717
                                                    heterodetic cyclic peptide 1433
                                                      microcystin 471
                                                        microcystin-LR 352
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.