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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-conocarpan
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Accession:CHEBI:69251 term browser browse the term
Definition:A member of the class of benzofurans that is 2,3-dihydro-1-benzofuran substituted by a methyl group at position 3, a prop-1-en-1-yl group at position 5 and a 4-hydroxyphenyl group at position 2. It is a lignan derivative isolated from the roots of Krameria lappacea.
Synonyms:exact_synonym: 4-{(2S,3S)-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran-2-yl}phenol
 related_synonym: Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-4-13-5-10-17-16(11-13)12(2)18(20-17)14-6-8-15(19)9-7-14/h3-12,18-19H,1-2H3/b4-3+/t12-,18-/m0/s1;   InChIKey=GXJSAHXNLJFDPO-OFXNJDNMSA-N;   SMILES=C\\C=C\\c1ccc2O[C@@H]([C@@H](C)c2c1)c1ccc(O)cc1
 xref_mesh: MESH:C447284
 xref: PMID:21800856;   Reaxys:8268058


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(+)-conocarpan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO SAR7334 inhibits the reaction [conocarpan results in increased cleavage of CASP3 protein] CTD PMID:31054997 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases activity
multiple interactions
ISO conocarpan results in increased activity of TRPC6 protein
SAR7334 inhibits the reaction [conocarpan results in increased activity of TRPC6 protein]
CTD PMID:31054997 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          (+)-conocarpan 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  oxacycle 17200
                                    benzofurans 3226
                                      (+)-conocarpan 2
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