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ONTOLOGY REPORT - ANNOTATIONS


Term:midodrine
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Accession:CHEBI:6933 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Synonyms:exact_synonym: rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
 related_synonym: (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide;   1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol;   2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide;   DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid;   Formula=C12H18N2O4;   InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);   InChIKey=PTKSEFOSCHHMPD-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CNC(=O)CN;   midodrina;   midodrinum
 xref: Beilstein:2384653 "Beilstein";   CAS:42794-76-3 "ChemIDplus";   CAS:42794-76-3 "KEGG COMPOUND";   DrugBank:DB00211;   Drug_Central:1803 "DrugCentral";   HMDB:HMDB0014356;   KEGG:C07890;   KEGG:D08220;   LINCS:LSM-1815
 xref_mesh: MESH:D008879
 xref: PMID:11096750 "Europe PMC";   PMID:15273244 "Europe PMC";   PMID:16676655 "Europe PMC";   PMID:17901021 "Europe PMC";   PMID:18410283 "Europe PMC";   PMID:18840368 "Europe PMC";   PMID:19522958 "Europe PMC";   PMID:20376815 "Europe PMC";   PMID:20844343 "Europe PMC";   PMID:21343575 "Europe PMC";   PMID:21801220 "Europe PMC";   PMID:22436941 "Europe PMC";   PMID:23051063 "Europe PMC";   Patent:GB1003659;   Patent:US3340298;   Reaxys:2384653 "Reaxys";   Wikipedia:Midodrine
 cyclic_relationship: is_conjugate_base_of CHEBI:73243


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midodrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pro-agent 8802
          prodrug 8592
            midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        amino acid 12445
                                          alpha-amino acid 7644
                                            L-alpha-amino acid 7309
                                              serine family amino acid 1770
                                                glycine 834
                                                  glycine derivative 828
                                                    glycinamide 73
                                                      midodrine 2
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