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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Paeonol
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Accession:CHEBI:69581 term browser browse the term
Definition:A methoxybenzene that has formula C9H10O3.
Synonyms:related_synonym: 1-(2-Hydroxy-4-methoxyphenyl)ethanone;   4-O-Methylresacetophenone;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3;   InChIKey=UILPJVPSNHJFIK-UHFFFAOYSA-N;   SMILES=COc1ccc(C(C)=O)c(O)c1
 alt_id: CHEBI:7890
 xref: CAS:552-41-0;   KEGG:C10712;   KNApSAcK:C00002704;   LINCS:LSM-24937
 xref_mesh: MESH:C013638
 xref: PMID:21954959


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Paeonol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased phosphorylation of AKT1 protein]
paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:26646421, PMID:29505745 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein] CTD PMID:29505745 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of BAX protein] CTD PMID:26646421, PMID:29505745 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
paeonol inhibits the reaction [Epirubicin results in decreased expression of BCL2 protein]
[Doxorubicin co-treated with paeonol] results in increased expression of BCL2 mRNA
CTD PMID:26646421, PMID:29505745, PMID:31307187 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein] CTD PMID:29505745 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased cleavage of CASP3 protein] CTD PMID:26646421, PMID:29505745 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in decreased activity of CAT protein] CTD PMID:26646421 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA] CTD PMID:31307187 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]] CTD PMID:22542583 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA] CTD PMID:31307187 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP paeonol results in increased expression of HES1 mRNA CTD PMID:31307187 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions
increases expression
EXP paeonol affects the reaction [Doxorubicin affects the expression of HEY1 mRNA]
paeonol results in increased expression of HEY1 mRNA
CTD PMID:31307187 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]] CTD PMID:22542583 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein] CTD PMID:22542583 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of IL2 protein] CTD PMID:26646421, PMID:29505745 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of IL6 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL6 protein] CTD PMID:22542583, PMID:26646421 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klf4 Kruppel like factor 4 increases expression
multiple interactions
EXP paeonol results in increased expression of KLF4 mRNA
paeonol inhibits the reaction [Doxorubicin results in decreased expression of KLF4 mRNA]
CTD PMID:31307187 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Maoa monoamine oxidase A decreases activity EXP paeonol results in decreased activity of MAOA protein CTD PMID:15120460 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity EXP paeonol results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mir1 microRNA 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in decreased expression of MIR1 mRNA] CTD PMID:29505745 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein] CTD PMID:29505745 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] CTD PMID:31307187 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myocd myocardin increases expression
multiple interactions
EXP paeonol results in increased expression of MYOCD mRNA
paeonol affects the reaction [Doxorubicin results in decreased expression of MYOCD mRNA]
CTD PMID:31307187 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of NFKB1 protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NFKB1 protein] CTD PMID:22542583 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein; [paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NFKBIA protein]
paeonol inhibits the reaction [Epirubicin results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:22542583, PMID:29505745 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:22542583 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 increases expression
increases cleavage
multiple interactions
EXP paeonol results in increased expression of NOTCH1 mRNA
paeonol results in increased cleavage of NOTCH1 protein
paeonol affects the reaction [Doxorubicin results in decreased expression of NOTCH1 mRNA]
CTD PMID:31307187 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased cleavage of PARP1 protein] CTD PMID:26646421 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:22542583 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of RELA protein]
paeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]
CTD PMID:22542583, PMID:29505745 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP paeonol inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein] CTD PMID:29505745 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP paeonol inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:31307187 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO paeonol inhibits the reaction [Epirubicin results in increased expression of TNF mRNA]; paeonol inhibits the reaction [Epirubicin results in increased expression of TNF protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein] CTD PMID:22542583, PMID:26646421, PMID:29505745 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            Paeonol 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      methoxybenzenes 1831
                                        Paeonol 33
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.