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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mometasone
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Accession:CHEBI:6970 term browser browse the term
Definition:A chlorinated steroid that has formula C22H28Cl2O4.
Synonyms:exact_synonym: 9,21-dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
 related_synonym: Formula=C22H28Cl2O4;   InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=QLIIKPVHVRXHRI-CXSFZGCWSA-N;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   mometasona;   mometasonum
 xref: CAS:105102-22-5;   DrugBank:DB00764;   KEGG:C07816;   KEGG:D08227


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mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850, PMID:19422381 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034, PMID:19422381 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297, PMID:10100995 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            mometasone 16
              mometasone furoate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxo steroid 9283
                                          3-oxo steroid 8811
                                            3-oxo-Delta(4) steroid 7939
                                              progesterone 2709
                                                Delta(1)-progesterone 236
                                                  mometasone 16
                                                    mometasone furoate 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.