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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:catalpol
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Accession:CHEBI:69797 term browser browse the term
Definition:An organic molecular entity that has formula C15H22O10.
Synonyms:related_synonym: Catalpinoside;   Catalposide, des-p-hydroxybenzoyl-;   Formula=C15H22O10;   InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1;   InChIKey=LHDWRKICQLTVDL-PZYDOOQISA-N;   SMILES=[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]1OC=C[C@@]2([H])[C@H](O)[C@]3([H])O[C@]3(CO)[C@@]12[H];   beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-
 alt_id: CHEBI:3464
 xref: CAS:2415-24-9;   KEGG:C09773;   KNApSAcK:C00003075
 xref_mesh: MESH:C078040
 xref: PMID:21568305


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catalpol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO catalpol inhibits the reaction [Galactose results in increased activity of ACHE protein] CTD PMID:23612000 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO catalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein] CTD PMID:23612000 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO catalpol inhibits the reaction [Galactose results in decreased expression of CHRM1 protein] CTD PMID:23612000 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]; catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]] CTD PMID:30682494 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [triptolide co-treated with catalpol co-treated with Saponins] results in increased expression of HMOX1 protein; [triptolide co-treated with catalpol] results in increased expression of HMOX1 protein CTD PMID:30682494 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Reactive Oxygen Species]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TLR4 mRNA]; catalpol results in decreased susceptibility to [Lipopolysaccharides co-treated with IFNG protein] CTD PMID:23164921 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO catalpol inhibits the reaction [Galactose results in increased expression of IL1B protein] CTD PMID:23612000 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [catalpol co-treated with Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [catalpol co-treated with triptolide] affects the localization of NFE2L2 protein; [triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein; catalpol inhibits the reaction [Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]]; catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]] CTD PMID:30682494 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:23164921 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [triptolide co-treated with catalpol] results in increased expression of NQO1 protein; catalpol promotes the reaction [[triptolide co-treated with Saponins] results in increased expression of NQO1 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NQO1 protein] CTD PMID:30682494 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA] CTD PMID:23164921 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TLR4 mRNA] CTD PMID:23164921 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO catalpol inhibits the reaction [Galactose results in increased expression of TNF protein] CTD PMID:23612000 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            catalpol 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      p-block molecular entity 19702
                        carbon group molecular entity 19608
                          organic molecular entity 19597
                            catalpol 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.