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ONTOLOGY REPORT - ANNOTATIONS


Term:dabigatran
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Accession:CHEBI:70752 term browser browse the term
Definition:An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism.
Synonyms:related_synonym: Formula=C25H25N7O3;   InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34);   InChIKey=YBSJFWOBGCMAKL-UHFFFAOYSA-N;   SMILES=Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1
 xref: CAS:211914-51-1 "KEGG DRUG";   KEGG:D09707
 xref_mesh: MESH:D000069604
 xref: PMID:21956605 "Europe PMC";   PMID:22215856 "Europe PMC";   PMID:22227958 "Europe PMC";   PMID:22314599 "Europe PMC";   PMID:22378612 "Europe PMC";   PMID:22411291 "Europe PMC";   PMID:22413715 "Europe PMC";   PMID:22431533 "Europe PMC";   PMID:22458575 "Europe PMC";   PMID:22494098 "Europe PMC";   PMID:22595629 "Europe PMC";   PMID:22612026 "Europe PMC";   PMID:22645678 "Europe PMC";   PMID:22700854 "Europe PMC";   PMID:22722043 "Europe PMC";   PMID:22740145 "Europe PMC";   PMID:22786838 "Europe PMC";   PMID:22834159 "Europe PMC";   PMID:22854367 "Europe PMC";   PMID:23020832 "Europe PMC";   PMID:23476049 "Europe PMC";   Patent:US2006222640;   Patent:US2008015176;   Patent:US6087380;   Patent:WO2004014894;   Patent:WO2006004575;   Patent:WO2006103206;   Patent:WO2008009638;   Patent:WO2008009639;   Reaxys:9168207 "Reaxys";   Wikipedia:Dabigatran


show annotations for term's descendants       view all columns           Sort by:
 
dabigatran term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AIF1 allograft inflammatory factor 1 JBrowse link 6 31,615,212 31,617,015 RGD:6480464
G F2 coagulation factor II, thrombin JBrowse link 11 46,719,201 46,739,506 RGD:6480464
G FGA fibrinogen alpha chain JBrowse link 4 154,583,126 154,590,742 RGD:6480464
G FGB fibrinogen beta chain JBrowse link 4 154,562,980 154,572,807 RGD:6480464
G FGG fibrinogen gamma chain JBrowse link 4 154,604,134 154,612,808 RGD:6480464
G GFAP glial fibrillary acidic protein JBrowse link 17 44,903,159 44,915,552 RGD:6480464
G MERTK MER proto-oncogene, tyrosine kinase JBrowse link 2 111,898,607 112,029,561 RGD:6480464
G PLP1 proteolipid protein 1 JBrowse link X 103,776,506 103,792,619 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23805
    role 23692
      biological role 23655
        inhibitor 21144
          beta-alanine 38
            beta-alanine derivative 38
              dabigatran 8
                N-(4-aminobutyl)dabigatranamide 0
                dabigatran etexilate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23805
    subatomic particle 23756
      composite particle 23756
        hadron 23756
          baryon 23756
            nucleon 23756
              atomic nucleus 23756
                atom 23756
                  main group element atom 23575
                    p-block element atom 23575
                      carbon group element atom 23289
                        carbon atom 23243
                          organic molecular entity 23243
                            organic group 21924
                              organic divalent group 21896
                                organodiyl group 21896
                                  carbonyl group 21868
                                    carbonyl compound 21868
                                      carboxylic acid 20917
                                        amino acid 13069
                                          non-proteinogenic amino acid 1770
                                            beta-amino acid 179
                                              beta-alanine 38
                                                beta-alanine derivative 38
                                                  dabigatran 8
                                                    N-(4-aminobutyl)dabigatranamide 0
                                                    dabigatran etexilate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.