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Term:omacetaxine mepesuccinate
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Accession:CHEBI:71019 term browser browse the term
Definition:A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
Synonyms:related_synonym: (2'R,3S,4S,5R)-(-)-homoharringtonine;   CGX-635;   Formula=C29H39NO9;   Homoharringtonine;   InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1;   InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N;   SMILES=[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21;   Synribo;   mepesuccinate d'omacetaxine;   mepesuccinato de omacetaxina;   omacetaxini mepesuccinas
 xref: Beilstein:5687925 "ChemIDplus";   CAS:26833-87-4 "ChemIDplus";   CAS:26833-87-4 "KEGG DRUG";   Drug_Central:4677 "DrugCentral";   KEGG:D08956;   LINCS:LSM-3716
 xref_mesh: MESH:C001652
 xref: PDBeChem:HMT;   PMID:20971952 "Europe PMC";   PMID:21152934 "Europe PMC";   PMID:21258877 "Europe PMC";   PMID:21294709 "Europe PMC";   PMID:21415308 "Europe PMC";   PMID:21418889 "Europe PMC";   PMID:21468038 "Europe PMC";   PMID:21509439 "Europe PMC";   PMID:21845438 "Europe PMC";   PMID:21916787 "Europe PMC";   PMID:22040954 "Europe PMC";   PMID:22054289 "Europe PMC";   PMID:22075327 "Europe PMC";   PMID:22289991 "Europe PMC";   PMID:22391162 "Europe PMC";   PMID:22580751 "Europe PMC";   PMID:22714632 "Europe PMC";   PMID:22896000 "Europe PMC";   PMID:22898909 "Europe PMC";   PMID:22917222 "Europe PMC";   PMID:22967374 "Europe PMC";   PMID:23053254 "Europe PMC";   PMID:23059828 "Europe PMC";   PMID:23086639 "Europe PMC";   PMID:23109844 "Europe PMC";   PMID:23456623 "Europe PMC";   Patent:US2010240887;   Patent:WO2007089878;   Reaxys:5687925 "Reaxys";   Wikipedia:Omacetaxine_mepesuccinate

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omacetaxine mepesuccinate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahi1 Abelson helper integration site 1 JBrowse link 1 16,478,127 16,601,769 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Tyr tyrosinase JBrowse link 1 151,012,598 151,106,802 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          apoptosis inducer 10835
            omacetaxine mepesuccinate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heterobicyclic compound 16240
                                      benzazepine 488
                                        benzazepine alkaloid 14
                                          cephalotaxine 6
                                            omacetaxine mepesuccinate 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.