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Term:carglumic acid
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Accession:CHEBI:71028 term browser browse the term
Definition:A urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia.
Synonyms:exact_synonym: N-carbamoyl-L-glutamic acid
 related_synonym: (2S)-2-(carbamoylamino)pentanedioic acid;   Carbaglu;   Carbamino-L-glutamic acid;   Carbamylglutamic acid;   Formula=C6H10N2O5;   InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1;   InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N;   L-N-Carbamoylglutamic acid;   SMILES=NC(=O)N[C@@H](CCC(O)=O)C(O)=O;   Ureidoglutaric acid;   acide carglumique;   acido carglumico;   acidum carglumicum
 xref: CAS:1188-38-1 "ChemIDplus";   CAS:1188-38-1 "KEGG COMPOUND";   CAS:1188-38-1 "KEGG DRUG";   DrugBank:DB06775;   Drug_Central:3068 "DrugCentral";   HMDB:HMDB0015673;   KEGG:C05829;   KEGG:D07130
 xref_mesh: MESH:C006895
 xref: MetaCyc:N-CARBAMYL-L-GLUTAMATE;   PMID:15055204 "Europe PMC";   PMID:17421020 "Europe PMC";   PMID:18234091 "Europe PMC";   PMID:18516804 "Europe PMC";   PMID:18604903 "Europe PMC";   PMID:20410539 "Europe PMC";   PMID:21207059 "Europe PMC";   PMID:21225012 "Europe PMC";   PMID:21403788 "Europe PMC";   PMID:21941437 "Europe PMC";   PMID:22858088 "Europe PMC";   Reaxys:1727929 "Reaxys";   Wikipedia:Carglumic_acid

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carglumic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          drug 19222
            orphan drug 71
              carglumic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      carboxylic acid 17971
                                        carboacyl group 17091
                                          univalent carboacyl group 17091
                                            carbamoyl group 16813
                                              carboxamide 16813
                                                N-acyl-amino acid 4940
                                                  N-acyl-L-amino acid 1876
                                                    N-acyl-L-alpha-amino acid 44
                                                      N-acyl-L-glutamic acid 40
                                                        carglumic acid 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.