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ONTOLOGY REPORT - ANNOTATIONS


Term:orphan drug
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Accession:CHEBI:71031 term browser browse the term
Definition:Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
Synonyms:related_synonym: orphan drugs
 xref: PMID:20036435 "Europe PMC";   PMID:20800761 "Europe PMC";   PMID:21180460 "Europe PMC";   PMID:21682893 "Europe PMC";   PMID:21947805 "Europe PMC";   PMID:22363762 "Europe PMC";   PMID:22366309 "Europe PMC";   PMID:22371464 "Europe PMC";   PMID:22731105 "Europe PMC";   PMID:22739138 "Europe PMC";   PMID:22747423 "Europe PMC";   PMID:22814659 "Europe PMC";   PMID:22814660 "Europe PMC";   PMID:22973866 "Europe PMC";   PMID:22981668 "Europe PMC";   PMID:22989856 "Europe PMC";   PMID:23013790 "Europe PMC";   PMID:23090701 "Europe PMC";   PMID:23109143 "Europe PMC";   PMID:23129684 "Europe PMC";   Wikipedia:Orphan_drug


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4-aminopyridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Dpysl4 dihydropyrimidinase-like 4 JBrowse link 1 211,423,022 211,438,533 RGD:6480464
G Gad2 glutamate decarboxylase 2 JBrowse link 17 89,171,576 89,234,770 RGD:6480464
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 JBrowse link 3 44,025,964 44,072,073 RGD:6480464
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D JBrowse link 1 101,819,068 101,859,146 RGD:6480464
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:6480464
G Jph3 junctophilin 3 JBrowse link 19 54,553,419 54,613,477 RGD:6480464
G Kcna10 potassium voltage-gated channel subfamily A member 10 JBrowse link 2 209,920,590 209,932,665 RGD:6480464
G Kcnd3 potassium voltage-gated channel subfamily D member 3 JBrowse link 2 207,923,775 208,140,727 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnip1 potassium voltage-gated channel interacting protein 1 JBrowse link 10 18,558,128 18,942,677 RGD:6480464
G Mag myelin-associated glycoprotein JBrowse link 1 89,345,325 89,360,905 RGD:6480464
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6480464
G Olr1583 olfactory receptor 1583 JBrowse link 13 91,725,324 91,726,265 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G RGD1311517 similar to RIKEN cDNA 9430015G10 JBrowse link 5 173,542,058 173,559,761 RGD:6480464
G S100a7a S100 calcium binding protein A7A JBrowse link 2 190,058,093 190,063,132 RGD:6480464
G Syn1 synapsin I JBrowse link X 1,321,315 1,379,202 RGD:6480464
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6480464
ivacaftor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
ixazomib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lat2 linker for activation of T cells family, member 2 JBrowse link 12 25,114,099 25,128,381 RGD:6480464
macitentan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
rifaximin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:6480464
G Cidec cell death-inducing DFFA-like effector c JBrowse link 4 145,377,482 145,390,497 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6480464
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:6480464
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:6480464
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      application 19246
        pharmaceutical 19108
          drug 19108
            orphan drug 58
              4-aminopyridine + 32
              ACT-333679 + 0
              Orkambi 0
              carglumic acid 0
              isavuconazole 0
              isavuconazonium sulfate 0
              ivacaftor + 1
              ixazomib + 1
              ixazomib citrate 0
              lenvatinib 0
              lenvatinib mesylate 0
              lumacaftor + 0
              macitentan 4
              rifaximin 21
              selexipag 0
              sodium phenylbutyrate 0
              uridine triacetate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.