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ONTOLOGY REPORT - ANNOTATIONS


Term:pazopanib
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Accession:CHEBI:71219 term browser browse the term
Definition:A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.
Synonyms:exact_synonym: 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
 related_synonym: Formula=C21H23N7O2S;   GW 78603;   GW786034;   InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);   InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N;   SMILES=CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1;   pazopanibum
 xref: CAS:444731-52-6 "ChemIDplus";   Drug_Central:4118 "DrugCentral";   LINCS:LSM-1114
 xref_mesh: MESH:C516667
 xref: PMID:21394443 "Europe PMC";   PMID:21766486 "Europe PMC";   PMID:21811833 "Europe PMC";   PMID:22112314 "Europe PMC";   PMID:22190407 "Europe PMC";   PMID:22233389 "Europe PMC";   PMID:22341567 "Europe PMC";   PMID:22359392 "Europe PMC";   PMID:22595799 "Europe PMC";   PMID:22679111 "Europe PMC";   PMID:22688250 "Europe PMC";   PMID:22716487 "Europe PMC";   PMID:22733110 "Europe PMC";   PMID:22733795 "Europe PMC";   PMID:22759480 "Europe PMC";   PMID:22766517 "Europe PMC";   PMID:22830347 "Europe PMC";   PMID:22861374 "Europe PMC";   PMID:22917595 "Europe PMC";   PMID:22984765 "Europe PMC";   PMID:23054212 "Europe PMC";   PMID:23064954 "Europe PMC";   PMID:23072642 "Europe PMC";   PMID:23088634 "Europe PMC";   PMID:23135778 "Europe PMC";   Patent:US2008293691;   Patent:WO2006020564;   Patent:WO2007064753;   Patent:WO2007143483;   Patent:WO2011058179;   Patent:WO2011069053;   Patent:WO2011150044;   Patent:WO2012106302;   Reaxys:11646488 "Reaxys";   Wikipedia:Pazopanib
 cyclic_relationship: is_conjugate_base_of CHEBI:71218


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pazopanib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            antineoplastic agent 16873
              pazopanib 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    main group molecular entity 19622
                      s-block molecular entity 19388
                        hydrogen molecular entity 19377
                          hydrides 18283
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17001
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        aromatic amine 13591
                                          aminopyrimidine 1051
                                            pazopanib 11
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