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Accession:CHEBI:71272 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes.
Synonyms:exact_synonym: (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
 related_synonym: (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile;   BMS-477118;   Formula=C18H25N3O2;   InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1;   InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N;   SMILES=[H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
 xref: CAS:361442-04-8 "ChemIDplus";   CAS:361442-04-8 "KEGG DRUG";   DrugBank:DB06335;   Drug_Central:4114 "DrugCentral";   HMDB:HMDB0015634;   KEGG:D08996
 xref_mesh: MESH:C502994
 xref: PMID:22001114 "Europe PMC";   PMID:22066527 "Europe PMC";   PMID:22081481 "Europe PMC";   PMID:22098472 "Europe PMC";   PMID:22132773 "Europe PMC";   PMID:22149373 "Europe PMC";   PMID:22192246 "Europe PMC";   PMID:22221000 "Europe PMC";   PMID:22232748 "Europe PMC";   PMID:22248301 "Europe PMC";   PMID:22292415 "Europe PMC";   PMID:22313154 "Europe PMC";   PMID:22313172 "Europe PMC";   PMID:22334441 "Europe PMC";   PMID:22349123 "Europe PMC";   PMID:22475049 "Europe PMC";   PMID:22496391 "Europe PMC";   PMID:22564773 "Europe PMC";   PMID:22668067 "Europe PMC";   PMID:22776778 "Europe PMC";   PMID:22823746 "Europe PMC";   PMID:22828124 "Europe PMC";   PMID:22932707 "Europe PMC";   PMID:22943617 "Europe PMC";   PMID:23137182 "Europe PMC";   Patent:US2005222242;   Patent:US2007172525;   Patent:WO2007078726;   Patent:WO2009022009;   Patent:WO2011125011;   Reaxys:10201614 "Reaxys";   Wikipedia:Saxagliptin

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saxagliptin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Dpp4 dipeptidylpeptidase 4 JBrowse link 3 48,291,055 48,372,672 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    chemical entity 19726
      group 19641
        pseudohalo group 2772
          cyano group 2772
            nitrile 2772
              saxagliptin 12
                saxagliptin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  saxagliptin 12
                                                    saxagliptin hydrate 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.