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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenazopyridine
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Accession:CHEBI:71416 term browser browse the term
Definition:A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
Synonyms:exact_synonym: 3-(phenyldiazenyl)pyridine-2,6-diamine
 related_synonym: 2,6-Diamino-3-(phenylazo)pyridine;   2,6-Diamino-3-phenylazopyridine;   3-(Phenylazo)-2,6-pyridinediamine;   Formula=C11H11N5;   InChI=1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,(H4,12,13,14);   InChIKey=QPFYXYFORQJZEC-UHFFFAOYSA-N;   SMILES=Nc1ccc(N=Nc2ccccc2)c(N)n1;   fenazopiridina;   phenazopyridinum
 alt_id: CHEBI:8057
 xref: Beilstein:184497;   CAS:94-78-0;   DrugBank:DB01438;   HMDB:HMDB0015506;   KEGG:C07429;   KEGG:D08346;   LINCS:LSM-3705
 xref_mesh: MESH:D010621
 xref: PMID:19300288;   PMID:19744778;   PMID:20196783;   PMID:20467292;   PMID:20636989;   PMID:20976818;   PMID:21147318;   PMID:21376167;   PMID:21681956;   PMID:21789523;   PMID:21856805;   PMID:22110938;   PMID:22987905;   PMID:23030327;   PMID:28166217;   Patent:US2009247628;   Patent:WO2008033466;   Patent:WO2010071878;   Reaxys:184497;   Wikipedia:Phenazopyridine
 cyclic_relationship: is_conjugate_base_of CHEBI:71420


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phenazopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenazopyridine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Utrn utrophin increases expression ISO Phenazopyridine results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            phenazopyridine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        aromatic amine 13634
                                          aminopyridine 359
                                            diaminopyridine 3
                                              phenazopyridine 2
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