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Accession:CHEBI:72317 term browser browse the term
Definition:A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.
Synonyms:exact_synonym: N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
 related_synonym: BMS 907351;   Formula=C28H24FN3O5;   InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);   InChIKey=ONIQOQHATWINJY-UHFFFAOYSA-N;   SMILES=COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC;   XL-184;   XL184
 xref: CAS:849217-68-1 "ChemIDplus";   CAS:849217-68-1 "KEGG DRUG";   Drug_Central:4715 "DrugCentral";   KEGG:D10062;   LINCS:LSM-1195
 xref_mesh: MESH:C558660
 xref: PMID:20127563 "Europe PMC";   PMID:21314233 "Europe PMC";   PMID:21460789 "Europe PMC";   PMID:21606412 "Europe PMC";   PMID:21613405 "Europe PMC";   PMID:21860001 "Europe PMC";   PMID:21862995 "Europe PMC";   PMID:21926191 "Europe PMC";   PMID:22146228 "Europe PMC";   PMID:22585997 "Europe PMC";   PMID:23104465 "Europe PMC";   PMID:23169517 "Europe PMC";   PMID:23248244 "Europe PMC";   PMID:23292257 "Europe PMC";   PMID:23292795 "Europe PMC";   PMID:23319755 "Europe PMC";   PMID:23319797 "Europe PMC";   PMID:23319867 "Europe PMC";   PMID:23335077 "Europe PMC";   PMID:23337762 "Europe PMC";   PMID:23337763 "Europe PMC";   PMID:23375349 "Europe PMC";   Patent:WO2012109510;   Reaxys:18631644 "Reaxys";   Wikipedia:Cabozantinib

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cabozantinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      application 19347
        pharmaceutical 19222
          drug 19222
            antineoplastic agent 16888
              cabozantinib 1
                cabozantinib malate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic acid 17972
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                dicarboxylic acid amide 3087
                                                  dicarboxylic acid diamide 2638
                                                    cabozantinib 1
                                                      cabozantinib malate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.