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ONTOLOGY REPORT - ANNOTATIONS


Term:lumiracoxib
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Accession:CHEBI:73044 term browser browse the term
Definition:An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
Synonyms:exact_synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
 related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid;   COX 189;   COX189;   Formula=C15H13ClFNO2;   InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20);   InChIKey=KHPKQFYUPIUARC-UHFFFAOYSA-N;   Prexige;   SMILES=Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1;   lumiracoxibum
 xref: CAS:220991-20-8 "ChemIDplus";   CAS:220991-20-8 "KEGG DRUG";   DrugBank:DB01283;   Drug_Central:1618 "DrugCentral";   HMDB:HMDB0015403;   KEGG:D03714
 xref_mesh: MESH:C473384
 xref: PDBeChem:LUR;   PMID:14965322 "Europe PMC";   PMID:15311562 "Europe PMC";   PMID:15456339 "Europe PMC";   PMID:17380211 "Europe PMC";   PMID:19800190 "Europe PMC";   PMID:21688392 "Europe PMC";   PMID:22069133 "Europe PMC";   PMID:22142375 "Europe PMC";   PMID:22621454 "Europe PMC";   PMID:22732767 "Europe PMC";   Reaxys:9784107 "Reaxys";   Wikipedia:Lumiracoxib


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lumiracoxib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:6480464
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:6480464
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:6480464
G Slco2a1 solute carrier organic anion transporter family, member 2a1 JBrowse link 8 111,495,443 111,577,320 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        anti-inflammatory agent 14938
          anti-inflammatory drug 13597
            non-steroidal anti-inflammatory drug 12680
              lumiracoxib 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          lumiracoxib 5
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