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ONTOLOGY REPORT - ANNOTATIONS


Term:deglymidodrine
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Accession:CHEBI:73248 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.
Synonyms:related_synonym: (+-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol;   1-(2',5'-dimethoxyphenyl)aminoethanol;   Formula=C10H15NO3;   InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3;   InChIKey=VFRCNXKYZVQYLX-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CN;   ST-1059;   alpha-(aminomethyl)-2,5-dimethoxybenzenemethanol;   de-glymidodrine;   desglymidodrine;   rac-2-amino-1-(2,5-dimethoxyphenyl)ethanol
 xref: CAS:3600-87-1 "ChemIDplus";   PMID:15537169 "Europe PMC";   PMID:16242885 "Europe PMC";   PMID:23051063 "Europe PMC";   Reaxys:3262168 "Reaxys"


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midodrine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          neurotransmitter agent 16396
            adrenergic agent 8906
              sympathomimetic agent 5385
                deglymidodrine 2
                  midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        primary amino compound 7788
                                          deglymidodrine 2
                                            midodrine 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.