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ONTOLOGY REPORT - ANNOTATIONS


Term:canagliflozin
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Accession:CHEBI:73274 term browser browse the term
Definition:A C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol
 related_synonym: 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene;   Formula=C24H25FO5S;   InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1;   InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N;   SMILES=[C@@H]1([C@@H]([C@H]([C@@](O[C@@H]1CO)(C2=CC=C(C(=C2)CC=3SC(=CC3)C4=CC=C(C=C4)F)C)[H])O)O)O
 xref: CAS:842133-18-0 "ChemIDplus";   Drug_Central:4758 "DrugCentral"
 xref_mesh: MESH:D000068896
 xref: PMID:20690635 "Europe PMC";   PMID:21457428 "Europe PMC";   PMID:22226086 "Europe PMC";   PMID:22355316 "Europe PMC";   PMID:22385274 "Europe PMC";   PMID:22492586 "Europe PMC";   PMID:22548646 "Europe PMC";   PMID:22621689 "Europe PMC";   PMID:22632452 "Europe PMC";   PMID:23087012 "Europe PMC";   PMID:23279307 "Europe PMC";   PMID:23370138 "Europe PMC";   PMID:23412078 "Europe PMC";   PMID:23464594 "Europe PMC";   PMID:23563279 "Europe PMC";   PMID:23564919 "Europe PMC";   PMID:23585665 "Europe PMC";   PMID:23590413 "Europe PMC";   Patent:US2008146515;   Patent:US2010099883;   Patent:US2012289694;   Patent:WO2009035969;   Patent:WO2011142478;   Reaxys:18362681 "Reaxys";   Wikipedia:Canagliflozin


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canagliflozin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6480464
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:6480464
G Slc5a2 solute carrier family 5 member 2 JBrowse link 1 199,682,688 199,688,809 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        inhibitor 18167
          sodium-glucose transport protein subtype 2 inhibitor 6
            canagliflozin 6
              canagliflozin hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            heteroorganic entity 19081
                              organochalcogen compound 18796
                                organooxygen compound 18708
                                  carbohydrates and carbohydrate derivatives 12115
                                    carbohydrate 12115
                                      carbohydrate derivative 11738
                                        glycosyl compound 10794
                                          C-glycosyl compound 226
                                            canagliflozin 6
                                              canagliflozin hydrate 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.