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ONTOLOGY REPORT - ANNOTATIONS


Term:DPDPE
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Accession:CHEBI:73356 term browser browse the term
Definition:A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
Synonyms:exact_synonym: (4S,7S,13S)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(L-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
 related_synonym: (D-Pen2,D-Pen5)-Enkephalin;   2,5-Pen-enkephalin;   D-penicillamine-(2,5)-enkephalin;   Formula=C30H39N5O7S2;   H-Tyr-c(D-Pen-Gly-Phe-D-Pen)-OH;   H-Tyr-cyclo-(D-Pen-Gly-Phe-D-Pen)-OH;   InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1;   InChIKey=MCMMCRYPQBNCPH-WMIMKTLMSA-N;   L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide;   SMILES=CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O;   [D-Pen(2)-D-Pen(5)]-enkephaline;   c[D-Pen(2,5)]-enkephalin;   cyclo-[D-Pen(2,5)]-enkephalin
 xref: CAS:88373-73-3;   KEGG:C20164
 xref_mesh: MESH:D020881
 xref: PMID:22995282;   PMID:23203254;   PMID:23564013;   PMID:23597562;   Reaxys:3586429


show annotations for term's descendants       view all columns           Sort by:
 
DPDPE term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:6480464
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:6480464
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:6480464
G Oprk1 opioid receptor, kappa 1 JBrowse link 5 13,742,655 13,760,460 RGD:6480464
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        pharmacological role 18818
          agonist 18195
            opioid receptor agonist 642
              delta-opioid receptor agonist 37
                DPDPE 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18465
                              organic divalent group 18458
                                organodiyl group 18458
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      carboxylic acid 18033
                                        carboacyl group 17190
                                          univalent carboacyl group 17190
                                            carbamoyl group 16927
                                              carboxamide 16927
                                                peptide 9371
                                                  cyclic peptide 8723
                                                    heterodetic cyclic peptide 1438
                                                      DPDPE 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.