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Accession:CHEBI:73356 term browser browse the term
Definition:A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
Synonyms:exact_synonym: (4S,7S,13S)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(L-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
 related_synonym: (D-Pen2,D-Pen5)-Enkephalin;   2,5-Pen-enkephalin;   D-penicillamine-(2,5)-enkephalin;   Formula=C30H39N5O7S2;   H-Tyr-c(D-Pen-Gly-Phe-D-Pen)-OH;   H-Tyr-cyclo-(D-Pen-Gly-Phe-D-Pen)-OH;   InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1;   InChIKey=MCMMCRYPQBNCPH-WMIMKTLMSA-N;   L-tyrosyl-3-mercapto-D-valylglycyl-L-phenylalanyl-3-mercapto-D-valine, cyclic (2-5)-disulfide;   SMILES=CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O;   [D-Pen(2)-D-Pen(5)]-enkephaline;   c[D-Pen(2,5)]-enkephalin;   cyclo-[D-Pen(2,5)]-enkephalin
 xref: CAS:88373-73-3 "ChemIDplus";   KEGG:C20164
 xref_mesh: MESH:D020881
 xref: PMID:22995282 "Europe PMC";   PMID:23203254 "Europe PMC";   PMID:23564013 "Europe PMC";   PMID:23597562 "Europe PMC";   Reaxys:3586429 "Reaxys"

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DPDPE term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLCO1B3 solute carrier organic anion transporter family member 1B3 JBrowse link 27 26,411,008 26,496,174 RGD:6480464

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  CHEBI ontology 225
    role 225
      biological role 225
        pharmacological role 146
          agonist 85
            opioid receptor agonist 2
              delta-opioid receptor agonist 1
                DPDPE 1
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  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 206
                        carbon atom 205
                          organic molecular entity 205
                            organic group 153
                              organic divalent group 152
                                organodiyl group 152
                                  carbonyl group 152
                                    carbonyl compound 152
                                      carboxylic acid 112
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                peptide 19
                                                  cyclic peptide 3
                                                    heterodetic cyclic peptide 2
                                                      DPDPE 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.