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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nafenopin
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Accession:CHEBI:7449 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-nafenopin. It is a peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an hypolipidemic agent.
Synonyms:exact_synonym: rac-2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
 related_synonym: 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid;   2-methyl-2-[p-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propionic acid;   C 13437 SU;   CH 13-437;   CH 13437;   Ciba 13437 SU;   D,L-nafenopin;   DL-nafenopin;   Melipan;   SU-13437;   alpha-methyl-alpha-(p-1,2,3,4-tetrahydronaphth-1-ylphenoxy)propionic acid;   nafenopina;   nafenopine;   nafenopinum
 xref: CAS:3771-19-5;   KEGG:C11371;   KEGG:D05102
 xref_mesh: MESH:D009255
 xref: PMID:10383891;   PMID:10573520;   PMID:10726969;   PMID:10869456;   PMID:10903494;   PMID:10964109;   PMID:11133804;   PMID:18079279;   PMID:3053229;   PMID:7009388;   PMID:9950074;   Patent:DE2018135;   Reaxys:2005820;   Wikipedia:Nafenopin


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nafenopin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein CTD PMID:15071170 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein CTD PMID:15071170 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression EXP Nafenopin affects the expression of ATP5F1B protein CTD PMID:10903494 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP Nafenopin results in increased expression of CAT protein
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein
CTD PMID:6845354, PMID:15071170 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Nafenopin results in increased expression of CHRM3 protein CTD PMID:10903494 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP Nafenopin results in increased expression of CYP4A1 mRNA
Okadaic Acid inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]; tautomycin inhibits the reaction [Nafenopin results in increased expression of CYP4A1 mRNA]
CTD PMID:18079279, PMID:19647067 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Nafenopin results in decreased expression of ECH1 protein CTD PMID:10903494 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions EXP [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA CTD PMID:15071170 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression EXP Nafenopin results in decreased expression of ERP29 protein CTD PMID:10903494 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Nafenopin results in increased expression of GSTA3 protein CTD PMID:8914623 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Nafenopin results in decreased expression of GSTM2 protein CTD PMID:8914623 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Nafenopin results in increased expression of HIBADH protein CTD PMID:10903494 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Nafenopin results in increased expression of HMOX1 protein CTD PMID:25690736 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Nafenopin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Nafenopin results in increased expression of P4HB protein CTD PMID:10903494 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
increases expression
decreases expression
decreases phosphorylation
ISO
EXP
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of CYP4A6 mRNA; aroclor 1260 inhibits the reaction [Nafenopin results in increased activity of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in increased expression of PPARA protein
[Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACAA1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of ACOX1 protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of CAT protein; [Nafenopin results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA; Okadaic Acid inhibits the reaction [Nafenopin results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein mutant form]; Okadaic Acid inhibits the reaction [Nafenopin results in increased activity of PPARA protein]
Nafenopin results in decreased expression of PPARA mRNA
Nafenopin results in increased activity of PPARA protein; Nafenopin results in increased activity of PPARA protein mutant form
CTD PMID:7684926, PMID:15071170, PMID:18079279, PMID:24812009 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Vim vimentin increases expression EXP Nafenopin results in increased expression of VIM protein CTD PMID:10903494 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            nafenopin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid 18
                                            (R)-nafenopin 18
                                              nafenopin 18
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