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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acivicin
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Accession:CHEBI:74545 term browser browse the term
Definition:An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria.
Synonyms:exact_synonym: (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
 related_synonym: (alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid;   (alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid;   AT-125;   Antibiotic AT 125;   Formula=C5H7ClN2O3;   InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1;   InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N;   NSC-163501;   SMILES=[H][C@]1(CC(Cl)=NO1)[C@H](N)C(O)=O;   U 42126;   U-42,126;   acivicine;   acivicino;   acivicinum
 xref: CAS:42228-92-2;   KEGG:D02755
 xref_mesh: MESH:C006303
 xref: MetaCyc:CPD0-1036;   PDBeChem:AVN;   PMID:11478776;   PMID:14586123;   PMID:2383250;   PMID:2894949;   PMID:3112985;   PMID:3165971;   PMID:3710919;   PMID:3915184;   PMID:6102405;   PMID:7026076;   PMID:7150366;   PMID:8060335;   PMID:9829740;   Reaxys:1074649;   Wikipedia:Acivicin


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acivicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA] CTD PMID:14766015 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
decreases activity
ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione CTD PMID:15629191, PMID:19419996 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          acivicin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        amino acid 14085
                                          alpha-amino acid 11550
                                            L-alpha-amino acid 11385
                                              non-proteinogenic L-alpha-amino acid 599
                                                acivicin 2
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