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ONTOLOGY REPORT - ANNOTATIONS


Term:aclacinomycin A
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Accession:CHEBI:74619 term browser browse the term
Definition:An anthracycline antibiotic that is produced by Streptomyces galilaeus and also has potent antineoplastic activity.
Synonyms:exact_synonym: methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
 related_synonym: Formula=C42H53NO15;   InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+/m0/s1;   InChIKey=USZYSDMBJDPRIF-SVEJIMAYSA-N;   MA 144-A1;   SMILES=CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)N(C)C)c2c(O)c3C(=O)c4c(O)cccc4C(=O)c3cc2[C@H]1C(=O)OC;   aclarubicin;   aclarubicina;   aclarubicine;   aclarubicinum
 xref: CAS:57576-44-0 "ChemIDplus";   CAS:57576-44-0 "KEGG COMPOUND";   Drug_Central:80 "DrugCentral";   KEGG:C18638;   KEGG:D02756;   KEGG:G09914
 xref_mesh: MESH:D015250
 xref: MetaCyc:CPD-12960;   PMID:19626543 "Europe PMC";   PMID:19744710 "Europe PMC";   PMID:20047095 "Europe PMC";   PMID:20399885 "Europe PMC";   PMID:20855424 "Europe PMC";   PMID:21130493 "Europe PMC";   PMID:21939347 "Europe PMC";   PMID:22077238 "Europe PMC";   PMID:22082134 "Europe PMC";   PMID:22374527 "Europe PMC";   PMID:22493369 "Europe PMC";   PMID:23418619 "Europe PMC";   PMID:23432721 "Europe PMC";   PMID:23533247 "Europe PMC";   PMID:23537708 "Europe PMC";   PMID:23595277 "Europe PMC";   PMID:23602475 "Europe PMC";   PMID:23613979 "Europe PMC";   PMID:23616245 "Europe PMC";   PMID:23664707 "Europe PMC";   Reaxys:4901152 "Reaxys";   Wikipedia:Aclarubicin
 cyclic_relationship: is_conjugate_base_of CHEBI:74353;   is_tautomer_of CHEBI:77980


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aclacinomycin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Dffa DNA fragmentation factor subunit alpha JBrowse link 5 165,922,893 165,935,822 RGD:6480464
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:6480464
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        antimicrobial agent 17199
          aclacinomycin A 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      ketone 15909
                                        cyclic ketone 13335
                                          quinone 8228
                                            acenoquinone 7413
                                              tetracenequinones 7289
                                                aklavinone 12
                                                  aclacinomycin A 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.