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Accession:CHEBI:7465 term browser browse the term
Definition:An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.
Synonyms:exact_synonym: 3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
 related_synonym: 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;   17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one;   Formula=C20H23NO4;   InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1;   InChIKey=DQCKKXVULJGBQN-XFWGSAIBSA-N;   N-Cyclopropylmethyl-14-hydroxydihydromorphinone;   N-Cyclopropylmethylnoroxymorphone;   SMILES=Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC1CC1
 xref: Beilstein:3596648 "Beilstein";   CAS:16590-41-3 "ChemIDplus";   CAS:16590-41-3 "KEGG COMPOUND";   CAS:16590-41-3 "NIST Chemistry WebBook";   DrugBank:DB00704;   Drug_Central:1765 "DrugCentral";   HMDB:HMDB0014842;   KEGG:C07253;   KEGG:D05113;   LINCS:LSM-3962
 xref_mesh: MESH:D009271
 xref: PMID:17023477 "Europe PMC";   PMID:24107112 "Europe PMC";   PMID:24659754 "Europe PMC";   PMID:27690505 "Europe PMC";   PMID:27700187 "Europe PMC";   PMID:27787292 "Europe PMC";   PMID:27813192 "Europe PMC";   PMID:27875802 "Europe PMC";   PMID:27922226 "Europe PMC";   PMID:27936293 "Europe PMC";   PMID:27987236 "Europe PMC";   PMID:28011389 "Europe PMC";   PMID:28029718 "Europe PMC";   PMID:28044452 "Europe PMC";   PMID:28061017 "Europe PMC";   PMID:28068780 "Europe PMC";   PMID:28106937 "Europe PMC";   PMID:28118565 "Europe PMC";   PMID:28130024 "Europe PMC";   PMID:28144772 "Europe PMC";   PMID:28153651 "Europe PMC";   PMID:28161142 "Europe PMC";   PMID:28168894 "Europe PMC";   PMID:28184294 "Europe PMC";   Patent:US3332950;   Reaxys:3596648 "Reaxys";   Wikipedia:Naltrexone
 cyclic_relationship: is_conjugate_base_of CHEBI:134688

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naltrexone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:6480464
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 JBrowse link 10 27,847,447 27,862,896 RGD:6480464
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 JBrowse link 10 27,973,694 28,193,072 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ogfr opioid growth factor receptor JBrowse link 3 176,093,662 176,099,949 RGD:6480464
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:6480464
G Oprk1 opioid receptor, kappa 1 JBrowse link 5 13,742,655 13,760,460 RGD:6480464
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:6480464
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        xenobiotic 18315
          naltrexone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heteropentacyclic compound 13161
                                      naltrexone 19
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.