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ONTOLOGY REPORT - ANNOTATIONS


Term:withanolide
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Accession:CHEBI:74716 term browser browse the term
Definition:Any steroid lactone that is a C28 steroid with a modified side chain forming a lactone ring and its substituted derivatives.
Synonyms:related_synonym: withanolides
 xref: LIPID_MAPS_instance:LMST01160000 "LIPID MAPS";   Wikipedia:Withanolide


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withaferin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2aip CDKN2A interacting protein JBrowse link 16 47,664,864 47,670,935 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:6480464
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:6480464
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6480464
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6480464
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6480464
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:6480464
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Procr protein C receptor JBrowse link 3 151,285,321 151,289,581 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Tubb5 tubulin, beta 5 class I JBrowse link 20 3,422,448 3,426,420 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        biochemical role 19125
          metabolite 19093
            eukaryotic metabolite 18735
              plant metabolite 17036
                withanolide 45
                  17alpha-hydroxywithanolide D 0
                  2,3-dihydro-3beta-O-sulfate withaferin A 0
                  2,3-dihydro-3beta-methoxy withaferin A 0
                  2,3-dihydrowithaferin A 0
                  20-hydroxytubocapsanolide A 0
                  23-hydroxytubocapsanolide A 0
                  3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                  Dinoxin B 0
                  LSM-5073 0
                  LSM-6432 0
                  LSM-6721 0
                  Taccalonolide A 0
                  minabeolide 1 0
                  minabeolide 2 0
                  minabeolide 4 0
                  minabeolide 5 0
                  minabeolide 8 0
                  paraminabeolide A 0
                  paraminabeolide B 0
                  paraminabeolide C 0
                  paraminabeolide D 0
                  paraminabeolide E 0
                  paraminabeolide F 0
                  tubocapsanolide A + 0
                  tubocapsanolide F 0
                  viscosalactone B 0
                  withaferin A + 45
                  withalongolide A 0
                  withalongolide B 0
                  withalongolide C 0
                  withalongolide D 0
                  withalongolide E 0
                  withalongolide G 0
                  withanolide D + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic ester 13946
                                        lactone 5857
                                          steroid lactone 361
                                            withanolide 45
                                              17alpha-hydroxywithanolide D 0
                                              2,3-dihydro-3beta-O-sulfate withaferin A 0
                                              2,3-dihydro-3beta-methoxy withaferin A 0
                                              2,3-dihydrowithaferin A 0
                                              20-hydroxytubocapsanolide A 0
                                              23-hydroxytubocapsanolide A 0
                                              3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                                              Dinoxin B 0
                                              LSM-5073 0
                                              LSM-6432 0
                                              LSM-6721 0
                                              Taccalonolide A 0
                                              minabeolide 1 0
                                              minabeolide 2 0
                                              minabeolide 4 0
                                              minabeolide 5 0
                                              minabeolide 8 0
                                              paraminabeolide A 0
                                              paraminabeolide B 0
                                              paraminabeolide C 0
                                              paraminabeolide D 0
                                              paraminabeolide E 0
                                              paraminabeolide F 0
                                              tubocapsanolide A + 0
                                              tubocapsanolide F 0
                                              viscosalactone B 0
                                              withaferin A + 45
                                              withalongolide A 0
                                              withalongolide B 0
                                              withalongolide C 0
                                              withalongolide D 0
                                              withalongolide E 0
                                              withalongolide G 0
                                              withanolide D + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.