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Accession:CHEBI:74774 term browser browse the term
Definition:A dicarboximide that is thalidomide substituted at position 5 by an ethenyl group, which in turn is substituted by a feruloyl group at position 2. The compound is a hybrid based on the structures of thalidomide and curcumin and has been found to exhibit cytotoxicity against human multiple myeloma cells.
Synonyms:exact_synonym: 2-(2,6-dioxopiperidin-3-yl)-5-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dien-1-yl]-1H-isoindole-1,3(2H)-dione
 related_synonym: 5-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dien-1-yl]thalidomide;   Formula=C25H20N2O7;   InChI=1S/C25H20N2O7/c1-34-21-13-15(5-10-20(21)29)3-7-16(28)6-2-14-4-8-17-18(12-14)25(33)27(24(17)32)19-9-11-22(30)26-23(19)31/h2-8,10,12-13,19,29H,9,11H2,1H3,(H,26,30,31)/b6-2+,7-3+;   InChIKey=HEMJTXBCAXHSBV-YPCIICBESA-N;   SMILES=COc1cc(\\C=C\\C(=O)\\C=C\\c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)ccc1O
 xref: PMID:23784627 "Europe PMC"

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  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            antineoplastic agent 16732
              5-[2-(feruloyl)ethen-1-yl]thalidomide 0
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  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
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              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
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                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteropolycyclic compound 17500
                                    organic heterobicyclic compound 15910
                                      benzopyrrole 5757
                                        isoindoles 509
                                          phthalimides 446
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 432
                                              (R)-thalidomide 432
                                                thalidomide 432
                                                  5-[2-(feruloyl)ethen-1-yl]thalidomide 0
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