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ONTOLOGY REPORT - ANNOTATIONS


Term:5-[2-(feruloyl)ethen-1-yl]thalidomide
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Accession:CHEBI:74774 term browser browse the term
Definition:A dicarboximide that is thalidomide substituted at position 5 by an ethenyl group, which in turn is substituted by a feruloyl group at position 2. The compound is a hybrid based on the structures of thalidomide and curcumin and has been found to exhibit cytotoxicity against human multiple myeloma cells.
Synonyms:exact_synonym: 2-(2,6-dioxopiperidin-3-yl)-5-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dien-1-yl]-1H-isoindole-1,3(2H)-dione
 related_synonym: 5-[(1E,4E)-5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dien-1-yl]thalidomide;   Formula=C25H20N2O7;   InChI=1S/C25H20N2O7/c1-34-21-13-15(5-10-20(21)29)3-7-16(28)6-2-14-4-8-17-18(12-14)25(33)27(24(17)32)19-9-11-22(30)26-23(19)31/h2-8,10,12-13,19,29H,9,11H2,1H3,(H,26,30,31)/b6-2+,7-3+;   InChIKey=HEMJTXBCAXHSBV-YPCIICBESA-N;   SMILES=COc1cc(\\C=C\\C(=O)\\C=C\\c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)ccc1O
 xref: PMID:23784627 "Europe PMC"


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                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteropolycyclic compound 17500
                                    organic heterobicyclic compound 15910
                                      benzopyrrole 5757
                                        isoindoles 509
                                          phthalimides 446
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 432
                                              (R)-thalidomide 432
                                                thalidomide 432
                                                  5-[2-(feruloyl)ethen-1-yl]thalidomide 0
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