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Accession:CHEBI:75045 term browser browse the term
Definition:An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.
Synonyms:exact_synonym: N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
 related_synonym: Formula=C23H20F3N5O2S2;   InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29);   InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
 xref: CAS:1195765-45-7 "ChemIDplus";   Drug_Central:4801 "DrugCentral";   KEGG:D10064;   LINCS:LSM-6303
 xref_mesh: MESH:C561627
 xref: PMID:22981500 "Europe PMC";   PMID:23237741 "Europe PMC";   PMID:23249624 "Europe PMC";   PMID:23276366 "Europe PMC";   PMID:23290787 "Europe PMC";   PMID:23317446 "Europe PMC";   PMID:23403819 "Europe PMC";   PMID:23463215 "Europe PMC";   PMID:23470635 "Europe PMC";   PMID:23515890 "Europe PMC";   PMID:23537694 "Europe PMC";   PMID:23552670 "Europe PMC";   PMID:23608920 "Europe PMC";   PMID:23617957 "Europe PMC";   PMID:23621583 "Europe PMC";   PMID:23656699 "Europe PMC";   PMID:23709751 "Europe PMC";   PMID:23714462 "Europe PMC";   PMID:23795808 "Europe PMC";   PMID:23807941 "Europe PMC";   PMID:23833299 "Europe PMC";   PMID:23844038 "Europe PMC";   PMID:23846776 "Europe PMC";   PMID:23870055 "Europe PMC";   PMID:23881668 "Europe PMC";   Patent:WO2011047238;   Reaxys:19689971 "Reaxys";   Wikipedia:Dabrafenib

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dabrafenib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:6480464
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Tgfbi transforming growth factor, beta induced JBrowse link 17 8,400,123 8,429,338 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              dabrafenib 16
                dabrafenib mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        aromatic amine 13592
                                          aminopyrimidine 1051
                                            dabrafenib 16
                                              dabrafenib mesylate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.