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Accession:CHEBI:75172 term browser browse the term
Definition:A 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes.
Synonyms:exact_synonym: 4-hydroxyandrost-4-ene-3,17-dione
 related_synonym: 4-OH-A;   4-OHAD;   4-hydroxy-4-androstene-3,17-dione;   4-hydroxy-Delta(4)-androstenedione;   4-hydroxyandrostenedione;   CGP 32349;   Formula=C19H26O3;   InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1;   InChIKey=OSVMTWJCGUFAOD-KZQROQTASA-N;   Lentaron;   SMILES=[H][C@@]12CCC3=C(O)C(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   formestano;   formestanum
 xref: CAS:566-48-3 "ChemIDplus";   DrugBank:DB08905;   Drug_Central:1238 "DrugCentral";   KEGG:D07260
 xref_mesh: MESH:C014594
 xref: PMID:1419285 "Europe PMC";   PMID:1637664 "Europe PMC";   PMID:17207827 "Europe PMC";   PMID:22354842 "Europe PMC";   PMID:23339113 "Europe PMC";   PMID:6665821 "Europe PMC";   Reaxys:4198373 "Reaxys";   Wikipedia:Formestane

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formestane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            antineoplastic agent 16550
              formestane 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      ketone 15780
                                        oxo steroid 9255
                                          3-oxo steroid 8779
                                            3-oxo-Delta(4) steroid 7902
                                              formestane 6
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