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ONTOLOGY REPORT - ANNOTATIONS


Term:trifluridine
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Accession:CHEBI:75179 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis.
Synonyms:exact_synonym: 2'-deoxy-5-(trifluoromethyl)uridine
 related_synonym: 5-(Trifluoromethyl)deoxyuridine;   5-Trifluoromethyl-2-deoxyuridine;   Formula=C10H11F3N2O5;   InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1;   InChIKey=VSQQQLOSPVPRAZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(c(=O)[nH]c1=O)C(F)(F)F;   Trifluoromethyldeoxyuridine;   Trifluorothymidine;   Viroptic;   trifluorothymine deoxyriboside;   trifluridina;   trifluridinum
 alt_id: CHEBI:9713
 xref: CAS:70-00-8 "ChemIDplus";   CAS:70-00-8 "KEGG DRUG";   DrugBank:DB00432;   Drug_Central:2743 "DrugCentral";   HMDB:HMDB0014576;   KEGG:D00391;   LINCS:LSM-5217
 xref_mesh: MESH:D014271
 xref: PMID:19816940 "Europe PMC";   PMID:19886911 "Europe PMC";   PMID:20861476 "Europe PMC";   PMID:21278209 "Europe PMC";   PMID:21491084 "Europe PMC";   PMID:22076553 "Europe PMC";   PMID:22607463 "Europe PMC";   PMID:22662200 "Europe PMC";   PMID:22735906 "Europe PMC";   PMID:22977515 "Europe PMC";   PMID:23343513 "Europe PMC";   PMID:23386782 "Europe PMC";   PMID:23521072 "Europe PMC";   PMID:23919755 "Europe PMC";   Reaxys:568095 "Reaxys";   Wikipedia:Trifluridine


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trifluridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          antimetabolite 8470
            trifluridine 10
              Lonsurf 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            heteroorganic entity 19055
                              organochalcogen compound 18781
                                organooxygen compound 18694
                                  carbohydrates and carbohydrate derivatives 12101
                                    carbohydrate 12101
                                      carbohydrate derivative 11727
                                        glycosyl compound 10788
                                          N-glycosyl compound 5309
                                            nucleoside 5170
                                              deoxyribonucleoside 2704
                                                2'-deoxyribonucleoside 2187
                                                  pyrimidine 2'-deoxyribonucleoside 331
                                                    trifluridine 10
                                                      Lonsurf 0
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