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ONTOLOGY REPORT - ANNOTATIONS


Term:picropodophyllotoxin
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Accession:CHEBI:75251 term browser browse the term
Definition:An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
Synonyms:exact_synonym: (5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
 related_synonym: Formula=C22H22O8;   InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1;   InChIKey=YJGVMLPVUAXIQN-HAEOHBJNSA-N;   Picropodophyllin;   SMILES=[H][C@]12COC(=O)[C@@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O
 alt_id: CHEBI:8204;   MESH:C415032
 xref: CAS:477-47-4 "ChemIDplus";   CAS:477-47-4 "KEGG COMPOUND";   HMDB:HMDB0031452;   KEGG:C10871;   KNApSAcK:C00002619
 xref_mesh: MESH:C415032
 xref: PMID:19070483 "Europe PMC";   PMID:19115065 "Europe PMC";   PMID:20150364 "Europe PMC";   PMID:21251888 "Europe PMC";   PMID:21330319 "Europe PMC";   PMID:21423728 "Europe PMC";   PMID:21968616 "Europe PMC";   PMID:22159423 "Europe PMC";   PMID:22215905 "Europe PMC";   PMID:22392915 "Europe PMC";   PMID:22495823 "Europe PMC";   PMID:23515289 "Europe PMC";   PMID:23624780 "Europe PMC";   PMID:23665331 "Europe PMC";   PMID:23699657 "Europe PMC";   PMID:23710710 "Europe PMC";   PMID:23797814 "Europe PMC";   PMID:24182354 "Europe PMC";   PMID:24406046 "Europe PMC";   PMID:25163779 "Europe PMC";   PMID:26021470 "Europe PMC";   PMID:26323364 "Europe PMC";   Patent:WO2012047172;   Reaxys:99161 "Reaxys"


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picropodophyllotoxin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              picropodophyllotoxin 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heterotetracyclic compound 4332
                                      furonaphthodioxole 667
                                        picropodophyllotoxin 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.