Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:arotinoid acid
go back to main search page
Accession:CHEBI:75261 term browser browse the term
Definition:A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).
Synonyms:exact_synonym: 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid
 related_synonym: AGN-191183;   Arotinoic acid;   CCRIS 3297;   Formula=C24H28O2;   InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+;   InChIKey=FOIVPCKZDPCJJY-JQIJEIRASA-N;   Ro 13-7410;   SMILES=C\\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C;   TTNPB
 alt_id: CHEBI:46258
 xref: CAS:71441-28-6 "ChemIDplus";   CAS:71441-28-6 "KEGG COMPOUND";   DrugBank:DB02877;   KEGG:C15634
 xref_mesh: MESH:C038864
 xref: PDBeChem:TTB;   PMID:1376755 "Europe PMC";   PMID:15109273 "Europe PMC";   PMID:19632163 "Europe PMC";   PMID:21559717 "Europe PMC";   PMID:2175182 "Europe PMC";   PMID:3378655 "Europe PMC";   Patent:CN1830950;   Reaxys:2008247 "Reaxys"


show annotations for term's descendants       view all columns           Sort by:
 
arotinoid acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CCNA2 cyclin A2 JBrowse link 4 121,816,444 121,823,883 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G CCND3 cyclin D3 JBrowse link 6 41,934,933 42,048,894 RGD:6480464
G CCNE1 cyclin E1 JBrowse link 19 29,811,991 29,824,312 RGD:6480464
G CDKN1B cyclin dependent kinase inhibitor 1B JBrowse link 12 12,717,270 12,722,383 RGD:6480464
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 9 22,002,903 22,009,313 RGD:6480464
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 JBrowse link 15 51,208,057 51,338,596 RGD:6480464
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 JBrowse link 10 93,073,475 93,077,885 RGD:6480464
G CYP4F11 cytochrome P450 family 4 subfamily F member 11 JBrowse link 19 15,912,370 15,934,866 RGD:6480464
G GJA1 gap junction protein alpha 1 JBrowse link 6 121,435,646 121,449,727 RGD:6480464
G HGF hepatocyte growth factor JBrowse link 7 81,699,006 81,770,438 RGD:6480464
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:6480464
G INS insulin JBrowse link 11 2,159,779 2,161,209 RGD:6480464
G IVL involucrin JBrowse link 1 152,908,545 152,911,886 RGD:6480464
G KRT13 keratin 13 JBrowse link 17 41,500,981 41,505,612 RGD:6480464
G KRT5 keratin 5 JBrowse link 12 52,514,575 52,520,394 RGD:6480464
G LRAT lecithin retinol acyltransferase JBrowse link 4 154,740,841 154,753,120 RGD:6480464
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 12 100,473,866 100,564,414 RGD:6480464
G NRL neural retina leucine zipper JBrowse link 14 24,078,662 24,114,949 RGD:6480464
G PDGFB platelet derived growth factor subunit B JBrowse link 22 39,223,359 39,244,982 RGD:6480464
G RARA retinoic acid receptor alpha JBrowse link 17 40,309,180 40,357,643 RGD:6480464
G RARB retinoic acid receptor beta JBrowse link 3 24,829,323 25,597,932 RGD:6480464
G RARG retinoic acid receptor gamma JBrowse link 12 53,210,566 53,232,256 RGD:6480464
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:6480464
G RBP1 retinol binding protein 1 JBrowse link 3 139,517,438 139,539,742 RGD:6480464
G RXRA retinoid X receptor alpha JBrowse link 9 134,326,455 134,440,586 RGD:6480464
G SCD stearoyl-CoA desaturase JBrowse link 10 100,347,233 100,364,826 RGD:6480464
G SLC2A4 solute carrier family 2 member 4 JBrowse link 17 7,281,718 7,288,257 RGD:6480464
G STS steroid sulfatase JBrowse link X 7,147,290 7,354,641 RGD:6480464
G TBC1D4 TBC1 domain family member 4 JBrowse link 13 75,283,503 75,483,144 RGD:6480464
G TGM1 transglutaminase 1 JBrowse link 14 24,249,114 24,263,177 RGD:6480464
G TGM2 transglutaminase 2 JBrowse link 20 38,127,385 38,166,508 RGD:6480464
G UCP1 uncoupling protein 1 JBrowse link 4 140,555,770 140,568,961 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23754
    role 23643
      biological role 23606
        aetiopathogenetic role 22204
          teratogenic agent 17715
            arotinoid acid 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 23754
    subatomic particle 23703
      composite particle 23703
        hadron 23703
          baryon 23703
            nucleon 23703
              atomic nucleus 23703
                atom 23703
                  main group element atom 23522
                    p-block element atom 23522
                      carbon group element atom 23232
                        carbon atom 23208
                          organic molecular entity 23208
                            organic group 21897
                              organic divalent group 21869
                                organodiyl group 21869
                                  carbonyl group 21840
                                    carbonyl compound 21840
                                      carboxylic acid 20885
                                        aromatic carboxylic acid 11284
                                          benzoic acids 11249
                                            arotinoid acid 37
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.