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ONTOLOGY REPORT - ANNOTATIONS


Term:splitomicin
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Accession:CHEBI:75272 term browser browse the term
Definition:A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Synonyms:exact_synonym: 1,2-dihydro-3H-benzo[f]chromen-3-one
 related_synonym: 1,2-dihydro-3H-naphtho[2,1-b]-pyran-3-one;   Formula=C13H10O2;   InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2;   InChIKey=ISFPDBUKMJDAJH-UHFFFAOYSA-N;   SMILES=O=C1CCc2c(O1)ccc1ccccc21
 xref: LINCS:LSM-2607
 xref_mesh: MESH:C444426
 xref: PMID:15115404;   PMID:18269226;   PMID:19327818;   PMID:21315612;   PMID:22634165;   Patent:KR20120128451;   Reaxys:161649


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splitomicin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Kcna5 potassium voltage-gated channel subfamily A member 5 JBrowse link 4 159,077,195 159,079,003 RGD:6480464
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      application 19359
        pharmaceutical 19228
          drug 19228
            hematologic agent 4262
              platelet aggregation inhibitor 3342
                splitomicin 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      carboxylic ester 14005
                                        lactone 5894
                                          delta-lactone 3796
                                            splitomicin 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.