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Accession:CHEBI:75310 term browser browse the term
Definition:A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
Synonyms:exact_synonym: 1-{2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone
 related_synonym: 2'-hydroxy-3'-propyl-4'-(4-(1H-tetrazol-5-yl)butoxy)acetophenone;   Formula=C16H22N4O3;   InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20);   InChIKey=MWYHLEQJTQJHSS-UHFFFAOYSA-N;   LY171883;   SMILES=CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O;   tomelukastum
 xref: CAS:88107-10-2 "ChemIDplus";   KEGG:D02851;   LINCS:LSM-3675
 xref_mesh: MESH:C044660
 xref: PMID:12429577 "Europe PMC";   PMID:18031150 "Europe PMC";   Reaxys:4238438 "Reaxys"

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tomelukast term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        anti-asthmatic agent 9171
          anti-asthmatic drug 8547
            tomelukast 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      ketone 15914
                                        methyl ketone 655
                                          acetophenones 141
                                            tomelukast 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.