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Accession:CHEBI:75379 term browser browse the term
Definition:A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II.
Synonyms:exact_synonym: 3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
 related_synonym: Formula=C18H16N2O2;   InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3;   InChIKey=LZAXPYOBKSJSEX-UHFFFAOYSA-N;   SMILES=Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1ccccc1
 xref: CAS:674289-55-5 "ChemIDplus";   LINCS:LSM-6195
 xref_mesh: MESH:C472645
 xref: PMID:15205456 "Europe PMC";   PMID:15240150 "Europe PMC";   PMID:15641783 "Europe PMC";   PMID:17994251 "Europe PMC";   PMID:20498707 "Europe PMC";   PMID:20956482 "Europe PMC";   PMID:21593446 "Europe PMC";   PMID:22507270 "Europe PMC";   PMID:22990759 "Europe PMC";   PMID:23291912 "Europe PMC";   PMID:23315199 "Europe PMC";   PMID:24662474 "Europe PMC";   Reaxys:10016269 "Reaxys"

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blebbistatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcar1 BCAR1 scaffold protein, Cas family member JBrowse link 19 43,932,543 43,967,452 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:6480464
G Myh2 myosin heavy chain 2 JBrowse link 10 53,711,895 53,738,164 RGD:6480464
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:6480464
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        inhibitor 18167
          blebbistatin 7
            (R)-blebbistatin 0
            (S)-blebbistatin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      ketone 15922
                                        oxyketone 8458
                                          alpha-oxyketone 8458
                                            alpha-hydroxy ketone 8458
                                              tertiary alpha-hydroxy ketone 8275
                                                blebbistatin 7
                                                  (R)-blebbistatin 0
                                                  (S)-blebbistatin 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.